(+/-)-1-[(tert-butyldimethylsilyl)oxy]-1-(3,4,5-trimethoxyphenyl)propan-2-one

Base Information

Chemical Name:(+/-)-1-[(tert-butyldimethylsilyl)oxy]-1-(3,4,5-trimethoxyphenyl)propan-2-one
CAS No.:1342305-51-4
Molecular Formula:C₁₈H₃₀O₅Si
Molecular Weight:354.519
Hs Code.:

Synonyms:(+/-)-1-[(tert-butyldimethylsilyl)oxy]-1-(3,4,5-trimethoxyphenyl)propan-2-one

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Chemical Property of (+/-)-1-[(tert-butyldimethylsilyl)oxy]-1-(3,4,5-trimethoxyphenyl)propan-2-one

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Technology Process of (+/-)-1-[(tert-butyldimethylsilyl)oxy]-1-(3,4,5-trimethoxyphenyl)propan-2-one

There total 7 articles about (+/-)-1-[(tert-butyldimethylsilyl)oxy]-1-(3,4,5-trimethoxyphenyl)propan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1342305-37-6
(+/-)-2-{[(tert-butyldimethylsilyl)oxy](3,4,5-trimethoxyphenyl)methyl}prop-2-enoic acid

: 1342305-51-4
(+/-)-1-[(tert-butyldimethylsilyl)oxy]-1-(3,4,5-trimethoxyphenyl)propan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / acetone / 0.08 h / 0 °C

2: sodium azide / acetone / 2 h / 20 °C

3: toluene / 2 h / Reflux; Inert atmosphere

4: water / 2 h / Reflux

With sodium azide; water; triethylamine; In acetone; toluene; 3: Curtius rearrangement;
DOI:10.1590/S0103-50532011000800022

Reference yield:

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 1342305-51-4
(+/-)-1-[(tert-butyldimethylsilyl)oxy]-1-(3,4,5-trimethoxyphenyl)propan-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: 1,4-diaza-bicyclo[2.2.2]octane / 30 °C / Sonication

2: 1H-imidazole; dimethyl sulfoxide / 20 °C / Inert atmosphere

3: water; lithium hydroxide / acetonitrile / 4 h / 50 - 60 °C

4: triethylamine / acetone / 0.08 h / 0 °C

5: sodium azide / acetone / 2 h / 20 °C

6: toluene / 2 h / Reflux; Inert atmosphere

7: water / 2 h / Reflux

With 1,4-diaza-bicyclo[2.2.2]octane; 1H-imidazole; sodium azide; water; dimethyl sulfoxide; triethylamine; lithium hydroxide; In acetone; toluene; acetonitrile; 1: Morita-Baylis-Hillman reaction / 6: Curtius rearrangement;
DOI:10.1590/S0103-50532011000800022

Reference yield:

: C₂₂H₃₄O₈Si

: 1342305-51-4
(+/-)-1-[(tert-butyldimethylsilyl)oxy]-1-(3,4,5-trimethoxyphenyl)propan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide / acetone / 2 h / 20 °C

2: toluene / 2 h / Reflux; Inert atmosphere

3: water / 2 h / Reflux

With sodium azide; water; In acetone; toluene; 2: Curtius rearrangement;
DOI:10.1590/S0103-50532011000800022