(R)-3-((4-(2-(6-(1H-pyrazol-1-yl)pyridin-3-yl)phenyl)thiazol-2-yl)(cyclopropyl)carbamoyl)-5-methylhexanoic acid

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Chemical Name:(R)-3-((4-(2-(6-(1H-pyrazol-1-yl)pyridin-3-yl)phenyl)thiazol-2-yl)(cyclopropyl)carbamoyl)-5-methylhexanoic acid
CAS No.:1351523-58-4
Molecular Formula:C₂₈H₂₉N₅O₃S
Molecular Weight:515.636
Hs Code.:

Synonyms:(R)-3-((4-(2-(6-(1H-pyrazol-1-yl)pyridin-3-yl)phenyl)thiazol-2-yl)(cyclopropyl)carbamoyl)-5-methylhexanoic acid

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Chemical Property of (R)-3-((4-(2-(6-(1H-pyrazol-1-yl)pyridin-3-yl)phenyl)thiazol-2-yl)(cyclopropyl)carbamoyl)-5-methylhexanoic acid

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Technology Process of (R)-3-((4-(2-(6-(1H-pyrazol-1-yl)pyridin-3-yl)phenyl)thiazol-2-yl)(cyclopropyl)carbamoyl)-5-methylhexanoic acid

There total 10 articles about (R)-3-((4-(2-(6-(1H-pyrazol-1-yl)pyridin-3-yl)phenyl)thiazol-2-yl)(cyclopropyl)carbamoyl)-5-methylhexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: tert-butyl (R)-3-((4-(2-(6-(1Hpyrazol-1-yl)pyridin-3-yl)phenyl)thiazol-2-yl)(cyclopropyl)carbamoyl)-5-methylhexanoate

: 1351523-58-4
(R)-3-((4-(2-(6-(1H-pyrazol-1-yl)pyridin-3-yl)phenyl)thiazol-2-yl)(cyclopropyl)carbamoyl)-5-methylhexanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmc.2018.09.015

Reference yield:

: 49851-55-0
2,2'-dibromoacetophenone

: 1351523-58-4
(R)-3-((4-(2-(6-(1H-pyrazol-1-yl)pyridin-3-yl)phenyl)thiazol-2-yl)(cyclopropyl)carbamoyl)-5-methylhexanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: ethanol / 2 h / Inert atmosphere; Reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 - 20 °C / Inert atmosphere

2.3: 6 h / Inert atmosphere; Reflux

3.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 60 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

With n-butyllithium; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; ethanol; hexane; dichloromethane; acetonitrile; 1.1: |Hantzsch Thiazole Synthesis / 2.3: |Suzuki Coupling;
DOI:10.1016/j.bmc.2018.09.015

Reference yield:

: 1229383-84-9
4-(2-bromophenyl)-N-cyclopropylthiazol-2-amine

: 1351523-58-4
(R)-3-((4-(2-(6-(1H-pyrazol-1-yl)pyridin-3-yl)phenyl)thiazol-2-yl)(cyclopropyl)carbamoyl)-5-methylhexanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 °C / Inert atmosphere

1.2: 2 h / -78 - 20 °C / Inert atmosphere

1.3: 6 h / Inert atmosphere; Reflux

2.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 60 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

With n-butyllithium; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; hexane; dichloromethane; acetonitrile; 1.3: |Suzuki Coupling;
DOI:10.1016/j.bmc.2018.09.015