Sulbactam sodium

Base Information

• Chemical Name: Sulbactam sodium
• CAS No.: 69388-84-7
• Molecular Formula: C8H10NNaO5S
• Molecular Weight: 255.227
• Hs Code.: 29349990
• Mol file: 69388-84-7.mol

Synonyms:4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid, 3,3-dimethyl-7-oxo-, 4,4-dioxide, sodium salt, (2S,5R)- (9CI);Penicillanic acid 1,1-dioxidesodium salt;Sodium 1,1-dioxypenicillanate;Sodium penicillanate 1,1-dioxide;Sodium sulbactam;Sulbactam sodium salt;Unasyn IM;

Chemical Property of Sulbactam sodium

Chemical Property:

• Appearance/Colour: COA
• Melting Point: 121-123°C(lit.)
• Boiling Point: 567.7oC at 760 mmHg
• Flash Point: 297.1oC
• PSA: 102.96000
• LogP: -1.11100
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility.: Freely soluble in water, sparingly soluble in ethyl acetate, very slightly soluble in ethanol (96 per cent). It is freely soluble in dilute acids.

Purity/Quality:

99% ^*data from raw suppliers

SulbactamSodiumSalt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 42/43
• Safety Statements: 22-24-36/37-45-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Description: Sulbactam sodium is a parenterally-active, β-lactamase inhibitor recently introduced as a 1: 1 combination product with cefoperazone. Like clavulanic acid, the first agent of this type to b e introduced, sulbactam enhances the effectiveness of β-lactam antibiotics against resistant strains.
• Uses: A semi-synthetic β-lactamase inhibitor. It is used in combination with β-lactam antibiotics as antibacterial.

Technology Process of Sulbactam sodium

There total 7 articles about Sulbactam sodium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.3%

sulbactum (68373-14-8,1217600-46-8) → sodium sulbactam (69388-84-7)

Guidance literature:

With sodium isooctanoate; In ethyl acetate;

Reference yield: 95.3%

penicillanic acid (87-53-6,820211-53-8) → sodium sulbactam (69388-84-7)

Guidance literature:

penicillanic acid; With potassium permanganate; sulfuric acid; acetic acid; In water; at 5 - 8 ℃; for 2.5h; Heating;

With sodium acetate; pyrographite; In ethanol; at 40 ℃; for 1h; Solvent;

Reference yield:

6,6-dibromopenicillanic acid-1,1-dioxide (76646-91-8) → sodium sulbactam (69388-84-7)

Guidance literature:

6,6-dibromopenicillanic acid-1,1-dioxide; With zinc; In water; at 0 ℃; pH=1.5 - 5.8;

With sodium 2-ethylhexanoic acid; In water; acetone; for 1h; Temperature;

upstream raw materials:

Diethyl phosphonate

allyl 6,6-dibromopenicillanate 1,1-dioxide

6,6-dibromopenicillanic acid-1,1-dioxide

sulbactum

Downstream raw materials:

(pivaloyloxy)methyl 6,6-dihydropenicillanate S,S-dioxide

(2R,4S)-4-benzyloxycarbonyl-2-methoxycarbonylmethyl-5,5-dimethyl-3-trifluoroacetylthiazolidine 1,1-dioxide

dibenzylamine salt of penicillanic acid 1,1-dioxide

iodomethyl penicillanate 1,1-dioxide

Refernces

• 1、 -. "Sulbactam sodium compound containing one-twentieth water and pharmaceutical composition thereof". . . Retrieved 2019/01/23.
• 2、 -. "Sulbactam sodium preparation method". Paragraph 0025; 0038; 0040; 0041. . Retrieved 2017/07/19.