(2R)-3-azido-2-(4-t-butylbenzyl)propyl pivalate

Base Information

Chemical Name:(2R)-3-azido-2-(4-t-butylbenzyl)propyl pivalate
CAS No.:1003002-93-4
Molecular Formula:C₁₉H₂₉N₃O₂
Molecular Weight:331.458
Hs Code.:

Synonyms:(2R)-3-azido-2-(4-t-butylbenzyl)propyl pivalate

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Chemical Property of (2R)-3-azido-2-(4-t-butylbenzyl)propyl pivalate

Chemical Property:

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Technology Process of (2R)-3-azido-2-(4-t-butylbenzyl)propyl pivalate

There total 6 articles about (2R)-3-azido-2-(4-t-butylbenzyl)propyl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1003002-91-2
(2R)-2-(4-t-butylbenzyl)-3-hydroxypropyl pivalate

: 1003002-93-4
(2R)-3-azido-2-(4-t-butylbenzyl)propyl pivalate

Guidance literature:: With diphenylphosphoranyl azide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/jm701049p

Reference yield:

: 18880-00-7
1-(bromomethyl)-4-(1,1-dimethylethyl)benzene

: 1003002-93-4
(2R)-3-azido-2-(4-t-butylbenzyl)propyl pivalate

Guidance literature:: Multi-step reaction with 7 steps

1: lithium hexamethyldisilazane; N,N,N,N,N,N-hexamethylphosphoric triamide / tetrahydrofuran

2: lithium aluminium tetrahydride / tetrahydrofuran

3: toluene-4-sulfonic acid

4: pyridine

5: periodic acid / diethyl ether

6: sodium tetrahydroborate / methanol

7: triphenylphosphine; diethylazodicarboxylate; diphenyl phosphoryl azide / tetrahydrofuran

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium tetrahydroborate; lithium aluminium tetrahydride; diphenyl phosphoryl azide; toluene-4-sulfonic acid; periodic acid; triphenylphosphine; lithium hexamethyldisilazane; diethylazodicarboxylate; In tetrahydrofuran; methanol; diethyl ether;
DOI:10.1016/j.bmcl.2014.04.054

Reference yield:

: 1003002-89-8
(2S)-2-(4-t-butylbenzyl)-3-oxopropyl pivalate

: 1003002-93-4
(2R)-3-azido-2-(4-t-butylbenzyl)propyl pivalate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol

2: triphenylphosphine; diethylazodicarboxylate; diphenyl phosphoryl azide / tetrahydrofuran

With sodium tetrahydroborate; diphenyl phosphoryl azide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmcl.2014.04.054