Technology Process of N-benzyl-3α,7α,24-trimethoxy-12-aza-5β-cholane
There total 8 articles about N-benzyl-3α,7α,24-trimethoxy-12-aza-5β-cholane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 12 h / 20 °C
2: diisobutylaluminium hydride / hexane; dichloromethane / 2.17 h / -78 °C
3: iodine; mercury(II) oxide / pyridine; benzene / 2 h / UV-irradiation; Inert atmosphere
4: trimethylsilyl iodide / tetrachloromethane / 60 - 70 °C / Inert atmosphere
5: 1,4-dioxane / 24 h / Reflux
With
trimethylsilyl iodide; iodine; diisobutylaluminium hydride; toluene-4-sulfonic acid; 3-chloro-benzenecarboperoxoic acid; mercury(II) oxide;
In
1,4-dioxane; pyridine; tetrachloromethane; hexane; dichloromethane; benzene;
1: Baeyer-Villiger oxidation;
DOI:10.1016/j.steroids.2010.12.003
- Guidance literature:
-
Multi-step reaction with 4 steps
1: diisobutylaluminium hydride / hexane; dichloromethane / 2.17 h / -78 °C
2: iodine; mercury(II) oxide / pyridine; benzene / 2 h / UV-irradiation; Inert atmosphere
3: trimethylsilyl iodide / tetrachloromethane / 60 - 70 °C / Inert atmosphere
4: 1,4-dioxane / 24 h / Reflux
With
trimethylsilyl iodide; iodine; diisobutylaluminium hydride; mercury(II) oxide;
In
1,4-dioxane; pyridine; tetrachloromethane; hexane; dichloromethane; benzene;
DOI:10.1016/j.steroids.2010.12.003
