N-(4-amino-5-chloro-2-methoxyphenyl)-1-cyclopentyl-4-piperidinecarboxamide

Base Information

Chemical Name:N-(4-amino-5-chloro-2-methoxyphenyl)-1-cyclopentyl-4-piperidinecarboxamide
CAS No.:86956-43-6
Molecular Formula:C₁₈H₂₆ClN₃O₂
Molecular Weight:351.876
Hs Code.:

Synonyms:N-(4-amino-5-chloro-2-methoxyphenyl)-1-cyclopentyl-4-piperidinecarboxamide

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Chemical Property of N-(4-amino-5-chloro-2-methoxyphenyl)-1-cyclopentyl-4-piperidinecarboxamide

Chemical Property:

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Technology Process of N-(4-amino-5-chloro-2-methoxyphenyl)-1-cyclopentyl-4-piperidinecarboxamide

There total 4 articles about N-(4-amino-5-chloro-2-methoxyphenyl)-1-cyclopentyl-4-piperidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69082-74-2
4-Chloro-2-(4-pyridinecarboxamido)anisole hydrochloride

: 86956-43-6
N-(4-amino-5-chloro-2-methoxyphenyl)-1-cyclopentyl-4-piperidinecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / H₂ / PtO₂ / ethanol / 6 h / 70 °C / 15514.4 Torr

2: 82 percent / fuming HNO₃, H₂SO₄ / acetic acid / 2 h

3: NaCNBH₃, EtOH/HCl / methanol; ethanol; tetrahydrofuran / 0.17 h

4: Fe / acetic acid; ethanol / Heating

With hydrogenchloride; ethanol; sulfuric acid; hydrogen; nitric acid; iron; sodium cyanoborohydride; platinum(IV) oxide; In tetrahydrofuran; methanol; ethanol; acetic acid;
DOI:10.1021/jm00366a017

Reference yield:

: 86956-50-5
N-(5-chloro-2-methoxy-4-nitrophenyl)-1-cyclopentyl-4-piperidinecarboxamide

: 86956-43-6
N-(4-amino-5-chloro-2-methoxyphenyl)-1-cyclopentyl-4-piperidinecarboxamide

Guidance literature:: With iron; In ethanol; acetic acid; Yield given; Heating;
DOI:10.1021/jm00366a017

Reference yield:

: 69082-73-1
N-(5-chloro-2-methoxyphenyl)-4-piperidinecarboxamide

: 86956-43-6
N-(4-amino-5-chloro-2-methoxyphenyl)-1-cyclopentyl-4-piperidinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / fuming HNO₃, H₂SO₄ / acetic acid / 2 h

2: NaCNBH₃, EtOH/HCl / methanol; ethanol; tetrahydrofuran / 0.17 h

3: Fe / acetic acid; ethanol / Heating

With hydrogenchloride; ethanol; sulfuric acid; nitric acid; iron; sodium cyanoborohydride; In tetrahydrofuran; methanol; ethanol; acetic acid;
DOI:10.1021/jm00366a017