(S)-1-<(R)-2-Benzyl-2-methyl-2H-azirin-3-yl>-2-(1-methoxy-1-methylethyl)pyrrolidin

Base Information

Chemical Name:(S)-1-<(R)-2-Benzyl-2-methyl-2H-azirin-3-yl>-2-(1-methoxy-1-methylethyl)pyrrolidin
CAS No.:171080-59-4
Molecular Formula:C₁₈H₂₆N₂O
Molecular Weight:286.417
Hs Code.:

Synonyms:(S)-1-<(R)-2-Benzyl-2-methyl-2H-azirin-3-yl>-2-(1-methoxy-1-methylethyl)pyrrolidin

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Chemical Property of (S)-1-<(R)-2-Benzyl-2-methyl-2H-azirin-3-yl>-2-(1-methoxy-1-methylethyl)pyrrolidin

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Technology Process of (S)-1-<(R)-2-Benzyl-2-methyl-2H-azirin-3-yl>-2-(1-methoxy-1-methylethyl)pyrrolidin

There total 4 articles about (S)-1-<(R)-2-Benzyl-2-methyl-2H-azirin-3-yl>-2-(1-methoxy-1-methylethyl)pyrrolidin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 484689-81-8
1-[(S)-2-(1-methoxy-1-methylethyl)pyrrolidin-1-yl]-2-methyl-3-phenylpropan-1-thione

: 171234-87-0
(S)-1-<(S)-2-Benzyl-2-methyl-2H-azirin-3-yl>-2-(1-methoxy-1-methylethyl)pyrrolidin

: 171080-59-4
(S)-1-<(R)-2-Benzyl-2-methyl-2H-azirin-3-yl>-2-(1-methoxy-1-methylethyl)pyrrolidin

Guidance literature:: 1-[(S)-2-(1-methoxy-1-methylethyl)pyrrolidin-1-yl]-2-methyl-3-phenylpropan-1-thione; In dichloromethane; N,N-dimethyl-formamide; toluene; at 0 ℃; for 1h;

With 1,4-diaza-bicyclo[2.2.2]octane; In tetrahydrofuran; at 0 ℃; for 0.333333h;

With sodium azide; at 20 ℃;
DOI:10.1002/1522-2675(200207)85:7<2073::AID-HLCA2073>3.0.CO;2-1

Reference yield:

: 118971-00-9,160142-25-6
(S)-(-)-2-(1-methoxy-1-methylethyl)-pyrrolidine

: 171080-59-4
(S)-1-<(R)-2-Benzyl-2-methyl-2H-azirin-3-yl>-2-(1-methoxy-1-methylethyl)pyrrolidin

Guidance literature:: Multi-step reaction with 4 steps

1.1: 92 percent / Et₃N / ethyl acetate / 0.5 h / 5 °C

2.1: 75 percent / LDA; LiClO₄ / tetrahydrofuran / -78 - 20 °C

3.1: 94 percent / Lawesson reagent / toluene / Heating

4.1: COCl₄ / dimethylformamide; CH₂Cl₂; toluene / 1 h / 0 °C

4.2: DABCO / tetrahydrofuran / 0.33 h / 0 °C

4.3: 20 percent / NaN₃ / 20 °C

With Lawessons reagent; lithium perchlorate; triethylamine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1002/1522-2675(200207)85:7<2073::AID-HLCA2073>3.0.CO;2-1

Reference yield:

: 484689-80-7
(RS,SS)-2-Methyl-3-phenyl-1-<2-(1-methoxy-1-methylethyl)pyrrolidin-1-yl>propan-1-on

: 171080-59-4
(S)-1-<(R)-2-Benzyl-2-methyl-2H-azirin-3-yl>-2-(1-methoxy-1-methylethyl)pyrrolidin

Guidance literature:: Multi-step reaction with 2 steps

1.1: 94 percent / Lawesson reagent / toluene / Heating

2.1: COCl₄ / dimethylformamide; CH₂Cl₂; toluene / 1 h / 0 °C

2.2: DABCO / tetrahydrofuran / 0.33 h / 0 °C

2.3: 20 percent / NaN₃ / 20 °C

With Lawessons reagent; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/1522-2675(200207)85:7<2073::AID-HLCA2073>3.0.CO;2-1