tert-butyl 2-(2-(benzyloxy)-5-(piperidin-1-yl)benzamido)-4-bromobenzoate

Base Information

Chemical Name:tert-butyl 2-(2-(benzyloxy)-5-(piperidin-1-yl)benzamido)-4-bromobenzoate
CAS No.:1237518-29-4
Molecular Formula:C₃₀H₃₃BrN₂O₄
Molecular Weight:565.507
Hs Code.:

Synonyms:tert-butyl 2-(2-(benzyloxy)-5-(piperidin-1-yl)benzamido)-4-bromobenzoate

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Chemical Property of tert-butyl 2-(2-(benzyloxy)-5-(piperidin-1-yl)benzamido)-4-bromobenzoate

Chemical Property:

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Technology Process of tert-butyl 2-(2-(benzyloxy)-5-(piperidin-1-yl)benzamido)-4-bromobenzoate

There total 5 articles about tert-butyl 2-(2-(benzyloxy)-5-(piperidin-1-yl)benzamido)-4-bromobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 890315-73-8
tert-butyl 2-amino-4-bromobenzoate

: 2-(benzyloxy)-5-(piperidin-1-yl)benzoic acid chloride

: 1237518-29-4
tert-butyl 2-(2-(benzyloxy)-5-(piperidin-1-yl)benzamido)-4-bromobenzoate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 1.5h;

Reference yield:

: 111-24-0
1,5-dibromo-pentane

: 1237518-29-4
tert-butyl 2-(2-(benzyloxy)-5-(piperidin-1-yl)benzamido)-4-bromobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 50 - 80 °C

2.1: sodium hydroxide; water / 1,4-dioxane / 3 h / 20 - 55 °C

2.2: pH 6.3

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C / Cooling with ice

4.1: pyridine / dichloromethane / 1.5 h / 20 °C

With pyridine; oxalyl dichloride; water; potassium carbonate; sodium hydroxide; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 5-amino-2-benzyloxybenzoic acid methyl ester

: 1237518-29-4
tert-butyl 2-(2-(benzyloxy)-5-(piperidin-1-yl)benzamido)-4-bromobenzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 50 - 80 °C

2.1: sodium hydroxide; water / 1,4-dioxane / 3 h / 20 - 55 °C

2.2: pH 6.3

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C / Cooling with ice

4.1: pyridine / dichloromethane / 1.5 h / 20 °C

With pyridine; oxalyl dichloride; water; potassium carbonate; sodium hydroxide; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;