(E)-4-Methyl-5-phenyl-pent-4-enoic acid 2-(3-ethyl-6-methoxy-5-methyl-4-oxo-4H-pyran-2-yl)-2-oxo-ethyl ester

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Chemical Name:(E)-4-Methyl-5-phenyl-pent-4-enoic acid 2-(3-ethyl-6-methoxy-5-methyl-4-oxo-4H-pyran-2-yl)-2-oxo-ethyl ester
CAS No.:177366-36-8
Molecular Formula:C₂₃H₂₆O₆
Molecular Weight:398.456
Hs Code.:

Synonyms:(E)-4-Methyl-5-phenyl-pent-4-enoic acid 2-(3-ethyl-6-methoxy-5-methyl-4-oxo-4H-pyran-2-yl)-2-oxo-ethyl ester

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Chemical Property of (E)-4-Methyl-5-phenyl-pent-4-enoic acid 2-(3-ethyl-6-methoxy-5-methyl-4-oxo-4H-pyran-2-yl)-2-oxo-ethyl ester

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Technology Process of (E)-4-Methyl-5-phenyl-pent-4-enoic acid 2-(3-ethyl-6-methoxy-5-methyl-4-oxo-4H-pyran-2-yl)-2-oxo-ethyl ester

There total 9 articles about (E)-4-Methyl-5-phenyl-pent-4-enoic acid 2-(3-ethyl-6-methoxy-5-methyl-4-oxo-4H-pyran-2-yl)-2-oxo-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 177366-35-7
(E)-4-Methyl-5-phenyl-pent-4-enoic acid 2-(3-ethyl-6-methoxy-5-methyl-4-oxo-4H-pyran-2-yl)-2-hydroxy-ethyl ester

: 177366-36-8
(E)-4-Methyl-5-phenyl-pent-4-enoic acid 2-(3-ethyl-6-methoxy-5-methyl-4-oxo-4H-pyran-2-yl)-2-oxo-ethyl ester

Guidance literature:: With Dess-Martin periodane; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1016/0040-4039(96)00483-2

Reference yield:

: 609-14-3
2-acetylpropanoic acid ethyl ester

: 177366-36-8
(E)-4-Methyl-5-phenyl-pent-4-enoic acid 2-(3-ethyl-6-methoxy-5-methyl-4-oxo-4H-pyran-2-yl)-2-oxo-ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 72 percent / NaH, n-BuLi / tetrahydrofuran / 1 h / 0 °C

2: 1.) NaH, LDA; 2.) DBU / 1.) THF, -78 deg C, 1 h; 2.) benzene, 60 deg C, 3 h

3: 61 percent / CH₂Cl₂ / 4 h / Ambient temperature

4: H₂ / Pd/C / methanol / 3 h / 50 °C

5: pyridine; CH₂Cl₂ / 2 h / Ambient temperature

6: K₂CO₃ / methanol / 0.5 h / Ambient temperature

7: OsO₄, NMO / acetonitrile; H₂O / 12 h / Ambient temperature

8: 67 percent / DCC, DMAP / CH₂Cl₂ / 0.5 h / 0 °C

9: 59 percent / Dess-Martin reagent / CH₂Cl₂ / 1 h / Ambient temperature

With dmap; osmium(VIII) oxide; n-butyllithium; N-methyl-2-indolinone; hydrogen; sodium hydride; potassium carbonate; Dess-Martin periodane; 1,8-diazabicyclo[5.4.0]undec-7-ene; dicyclohexyl-carbodiimide; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; dichloromethane; water; acetonitrile;
DOI:10.1016/0040-4039(96)00483-2

Reference yield:

: 29304-40-3
2-methyl-3-oxohexanoic acid ethyl ester

: 177366-36-8
(E)-4-Methyl-5-phenyl-pent-4-enoic acid 2-(3-ethyl-6-methoxy-5-methyl-4-oxo-4H-pyran-2-yl)-2-oxo-ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 1.) NaH, LDA; 2.) DBU / 1.) THF, -78 deg C, 1 h; 2.) benzene, 60 deg C, 3 h

2: 61 percent / CH₂Cl₂ / 4 h / Ambient temperature

3: H₂ / Pd/C / methanol / 3 h / 50 °C

4: pyridine; CH₂Cl₂ / 2 h / Ambient temperature

5: K₂CO₃ / methanol / 0.5 h / Ambient temperature

6: OsO₄, NMO / acetonitrile; H₂O / 12 h / Ambient temperature

7: 67 percent / DCC, DMAP / CH₂Cl₂ / 0.5 h / 0 °C

8: 59 percent / Dess-Martin reagent / CH₂Cl₂ / 1 h / Ambient temperature

With dmap; osmium(VIII) oxide; N-methyl-2-indolinone; hydrogen; sodium hydride; potassium carbonate; Dess-Martin periodane; 1,8-diazabicyclo[5.4.0]undec-7-ene; dicyclohexyl-carbodiimide; lithium diisopropyl amide; palladium on activated charcoal; In pyridine; methanol; dichloromethane; water; acetonitrile;
DOI:10.1016/0040-4039(96)00483-2