5-chloro-2-(hydroxymethyl)-6-methyl-6'-{4-[(trifluoromethyl)-oxy]phenyl}-3,3'-bipyridin-4(1H)-one

Base Information

Chemical Name:5-chloro-2-(hydroxymethyl)-6-methyl-6'-{4-[(trifluoromethyl)-oxy]phenyl}-3,3'-bipyridin-4(1H)-one
CAS No.:1257875-10-7
Molecular Formula:C₁₉H₁₄ClF₃N₂O₃
Molecular Weight:410.78
Hs Code.:

Synonyms:5-chloro-2-(hydroxymethyl)-6-methyl-6'-{4-[(trifluoromethyl)-oxy]phenyl}-3,3'-bipyridin-4(1H)-one

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Chemical Property of 5-chloro-2-(hydroxymethyl)-6-methyl-6'-{4-[(trifluoromethyl)-oxy]phenyl}-3,3'-bipyridin-4(1H)-one

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Technology Process of 5-chloro-2-(hydroxymethyl)-6-methyl-6'-{4-[(trifluoromethyl)-oxy]phenyl}-3,3'-bipyridin-4(1H)-one

There total 10 articles about 5-chloro-2-(hydroxymethyl)-6-methyl-6'-{4-[(trifluoromethyl)-oxy]phenyl}-3,3'-bipyridin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 2-(hydroxymethyl)-6-methyl-6'-{4-[(trifluoromethyl)oxy]phenyl}-3,3'-bipyridin-4(1H)-one

: 1257875-10-7
5-chloro-2-(hydroxymethyl)-6-methyl-6'-{4-[(trifluoromethyl)-oxy]phenyl}-3,3'-bipyridin-4(1H)-one

Guidance literature:: With trichloroisocyanuric acid; In methanol; dichloromethane; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.7b01256

Reference yield:

: 1257875-15-2
5-bromo-2-{4-[(trifluoromethyl)oxy]phenyl}pyridine

: 1257875-10-7
5-chloro-2-(hydroxymethyl)-6-methyl-6'-{4-[(trifluoromethyl)-oxy]phenyl}-3,3'-bipyridin-4(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; potassium acetate / 1,4-dioxane / 5 h / 100 °C / Inert atmosphere

1.2: 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / toluene; water; ethanol / 3 h / 80 °C / Inert atmosphere

3.1: ammonium hydroxide / ethanol / 0.83 h / 140 °C / Microwave irradiation; Sealed tube

4.1: trichloroisocyanuric acid / dichloromethane; methanol / 1 h / 0 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; ammonium hydroxide; trichloroisocyanuric acid; potassium acetate; sodium carbonate; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; toluene; 2.1: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.7b01256

Reference yield:

: 958457-26-6
3-hydroxy-6-methyl-2-(O-tert-butyldimethylsilyl)hydroxymethylpyran-4(1H)-one

: 1257875-10-7
5-chloro-2-(hydroxymethyl)-6-methyl-6'-{4-[(trifluoromethyl)-oxy]phenyl}-3,3'-bipyridin-4(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 1.5 h / 20 °C / Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / toluene; water; ethanol / 3 h / 80 °C / Inert atmosphere

3: ammonium hydroxide / ethanol / 0.83 h / 140 °C / Microwave irradiation; Sealed tube

4: trichloroisocyanuric acid / dichloromethane; methanol / 1 h / 0 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; ammonium hydroxide; trichloroisocyanuric acid; sodium carbonate; potassium carbonate; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; 2: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.7b01256