5-(2-cyanoethyl)hydroxymethyl-5'-(4,4'-dimethoxytrityl)-2'-deoxycytidine

Base Information

• Chemical Name: 5-(2-cyanoethyl)hydroxymethyl-5'-(4,4'-dimethoxytrityl)-2'-deoxycytidine
• CAS No.: 1277097-09-2
• Molecular Formula: C₃₄H₃₆N₄O₇
• Molecular Weight: 612.682
• Mol file: 1277097-09-2.mol

Synonyms:5-(2-cyanoethyl)hydroxymethyl-5'-(4,4'-dimethoxytrityl)-2'-deoxycytidine

Chemical Property of 5-(2-cyanoethyl)hydroxymethyl-5'-(4,4'-dimethoxytrityl)-2'-deoxycytidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(2-cyanoethyl)hydroxymethyl-5'-(4,4'-dimethoxytrityl)-2'-deoxycytidine

There total 11 articles about 5-(2-cyanoethyl)hydroxymethyl-5'-(4,4'-dimethoxytrityl)-2'-deoxycytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

5-(2-cyanoethyl)hydroxymethyl-5'-(4,4'-dimethoxytrityl)-2'-deoxyuridine (1277097-06-9) → 5-(2-cyanoethyl)hydroxymethyl-5'-(4,4'-dimethoxytrityl)-2'-deoxycytidine (1277097-09-2)

Guidance literature:

5-(2-cyanoethyl)hydroxymethyl-5'-(4,4'-dimethoxytrityl)-2'-deoxyuridine; With 1,8-diazabicyclo[5.4.0]undec-7-ene; ((3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V); In N,N-dimethyl-formamide; at 20 ℃; for 0.0166667h;

With ammonium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 4h; Reagent/catalyst; Time;

DOI:10.1016/j.tet.2018.10.046

Reference yield: 57.0%

5-(2-cyanoethyl)oxymethyl-5'-(4,4'-dimethoxytrityl)-2'-deoxyuridine → 5-(2-cyanoethyl)hydroxymethyl-5'-(4,4'-dimethoxytrityl)-2'-deoxycytidine (1277097-09-2)

Guidance literature:

5-(2-cyanoethyl)oxymethyl-5'-(4,4'-dimethoxytrityl)-2'-deoxyuridine; With 2,4,6-triisopropylphenylsulfonyl chloride; tetrabutylammomium bromide; sodium carbonate; In dichloromethane; water; Inert atmosphere;

With ammonium hydroxide; In 1,4-dioxane; Sealed tube;

DOI:10.1016/j.bmcl.2015.01.070

Reference yield:

C49H57N3O10S → 5-(2-cyanoethyl)hydroxymethyl-5'-(4,4'-dimethoxytrityl)-2'-deoxycytidine (1277097-09-2)

Guidance literature:

With ammonia; In 1,4-dioxane; water; for 16h;

DOI:10.1016/j.bmcl.2010.12.098

upstream raw materials:

(MeO)2Tr-OAc

5-(2-cyanoethyl)hydroxymethyl-2'-deoxyuridine

5-(2-cyanoethyl)hydroxymethyl-5'-(4,4'-dimethoxytrityl)-2'-deoxyuridine

2'-deoxyuridine

Downstream raw materials:

N₄-benzoyl-5-(2-cyanoethyl)hydroxymethyl-5'-(4,4'-dimethoxytrityl)-2'-deoxycytidine-3'-[N,N-diisopropyl-N-cyanoethyl]phosphoramidite

N₄-benzoyl-5-(2-cyanoethyl)hydroxymethyl-5'-(4,4'-dimethoxytrityl)-2'-deoxycytidine