6-N-benzoyl-5'-O-benzyl-3'-O-(tert-butyldimethylsilyl)-6-N-(tert-butyloxycarbonyl)-2'-deoxy-4'α-methoxycarbonyladenosine

Base Information

Chemical Name:6-N-benzoyl-5'-O-benzyl-3'-O-(tert-butyldimethylsilyl)-6-N-(tert-butyloxycarbonyl)-2'-deoxy-4'α-methoxycarbonyladenosine
CAS No.:470699-86-6
Molecular Formula:C₃₇H₄₇N₅O₈Si
Molecular Weight:717.894
Hs Code.:

Synonyms:6-N-benzoyl-5'-O-benzyl-3'-O-(tert-butyldimethylsilyl)-6-N-(tert-butyloxycarbonyl)-2'-deoxy-4'α-methoxycarbonyladenosine

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Chemical Property of 6-N-benzoyl-5'-O-benzyl-3'-O-(tert-butyldimethylsilyl)-6-N-(tert-butyloxycarbonyl)-2'-deoxy-4'α-methoxycarbonyladenosine

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Technology Process of 6-N-benzoyl-5'-O-benzyl-3'-O-(tert-butyldimethylsilyl)-6-N-(tert-butyloxycarbonyl)-2'-deoxy-4'α-methoxycarbonyladenosine

There total 1 articles about 6-N-benzoyl-5'-O-benzyl-3'-O-(tert-butyldimethylsilyl)-6-N-(tert-butyloxycarbonyl)-2'-deoxy-4'α-methoxycarbonyladenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 208175-48-8
5'-O-benzyl-6-N-benzoyl-3'-O-(tert-butyldimethylsilyl)-2'-deoxy-4'α-methoxycarbonyl-D-adenosine

: 470699-86-6
6-N-benzoyl-5'-O-benzyl-3'-O-(tert-butyldimethylsilyl)-6-N-(tert-butyloxycarbonyl)-2'-deoxy-4'α-methoxycarbonyladenosine

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/S0040-4020(02)00557-4

Reference yield: 66.0%

: 470699-86-6
6-N-benzoyl-5'-O-benzyl-3'-O-(tert-butyldimethylsilyl)-6-N-(tert-butyloxycarbonyl)-2'-deoxy-4'α-methoxycarbonyladenosine

: 470699-87-7
5'-O-benzyl-6-N-(tert-butyloxycarbonyl)-4'α-carboxyl-2'-deoxyadenosine

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; water;
DOI:10.1016/S0040-4020(02)00557-4

Reference yield:

: 470699-86-6
6-N-benzoyl-5'-O-benzyl-3'-O-(tert-butyldimethylsilyl)-6-N-(tert-butyloxycarbonyl)-2'-deoxy-4'α-methoxycarbonyladenosine

: 470699-89-9
5'-O-benzyl-4'α-[(2-(2-bromophenyl)-2-methylpropylthio)carbonyl]-6-N-(tert-butyloxycarbonyl)-2'-deoxyadenosine

Guidance literature:: Multi-step reaction with 2 steps

1: 66 percent / potassium tert-butoxide / tetrahydrofuran; H₂O

2: 73 percent / BOP-Cl; triethylamine / tetrahydrofuran; CH₂Cl₂ / 2 h / Heating

With potassium tert-butylate; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/S0040-4020(02)00557-4