2-Hydroxy-2-{(3S,4R)-2-oxo-3-[1-(2,2,2-trichloro-ethoxycarbonyloxy)-ethyl]-4-tritylsulfanyl-azetidin-1-yl}-malonic acid diallyl ester

Base Information

Chemical Name:2-Hydroxy-2-{(3S,4R)-2-oxo-3-[1-(2,2,2-trichloro-ethoxycarbonyloxy)-ethyl]-4-tritylsulfanyl-azetidin-1-yl}-malonic acid diallyl ester
CAS No.:87617-38-7
Molecular Formula:C₃₆H₃₄Cl₃NO₉S
Molecular Weight:763.092
Hs Code.:

Synonyms:2-Hydroxy-2-{(3S,4R)-2-oxo-3-[1-(2,2,2-trichloro-ethoxycarbonyloxy)-ethyl]-4-tritylsulfanyl-azetidin-1-yl}-malonic acid diallyl ester

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Chemical Property of 2-Hydroxy-2-{(3S,4R)-2-oxo-3-[1-(2,2,2-trichloro-ethoxycarbonyloxy)-ethyl]-4-tritylsulfanyl-azetidin-1-yl}-malonic acid diallyl ester

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Technology Process of 2-Hydroxy-2-{(3S,4R)-2-oxo-3-[1-(2,2,2-trichloro-ethoxycarbonyloxy)-ethyl]-4-tritylsulfanyl-azetidin-1-yl}-malonic acid diallyl ester

There total 1 articles about 2-Hydroxy-2-{(3S,4R)-2-oxo-3-[1-(2,2,2-trichloro-ethoxycarbonyloxy)-ethyl]-4-tritylsulfanyl-azetidin-1-yl}-malonic acid diallyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 87605-44-5
diallyl ketomalonate

: 87605-43-4
(3S,4R)-3-[1-(2,2,2)-trichloroethoxycarbonyloxyethyl]-4-(triphenylmethylthio)-azetidin-2-one

: 87617-38-7
2-Hydroxy-2-{(3S,4R)-2-oxo-3-[1-(2,2,2-trichloro-ethoxycarbonyloxy)-ethyl]-4-tritylsulfanyl-azetidin-1-yl}-malonic acid diallyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran;
DOI:10.1016/S0040-4039(00)88129-0

Reference yield:

: 87617-38-7
2-Hydroxy-2-{(3S,4R)-2-oxo-3-[1-(2,2,2-trichloro-ethoxycarbonyloxy)-ethyl]-4-tritylsulfanyl-azetidin-1-yl}-malonic acid diallyl ester

: 2-Chloro-2-{(3S,4R)-2-oxo-3-[1-(2,2,2-trichloro-ethoxycarbonyloxy)-ethyl]-4-tritylsulfanyl-azetidin-1-yl}-malonic acid diallyl ester

Guidance literature:: With pyridine; thionyl chloride; In dichloromethane; Yield given;
DOI:10.1016/S0040-4039(00)88129-0

Reference yield:

: 87617-38-7
2-Hydroxy-2-{(3S,4R)-2-oxo-3-[1-(2,2,2-trichloro-ethoxycarbonyloxy)-ethyl]-4-tritylsulfanyl-azetidin-1-yl}-malonic acid diallyl ester

: 87605-45-6
2-[(3S,4R)-3-(1-Hydroxy-ethyl)-2-oxo-4-tritylsulfanyl-azetidin-1-yl]-malonic acid diallyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂, pyridine / CH₂Cl₂

2: zinc, AcOH / CH₂Cl₂; propan-2-ol

With pyridine; thionyl chloride; acetic acid; zinc; In dichloromethane; isopropyl alcohol;
DOI:10.1016/S0040-4039(00)88129-0