(R)-4-{3,5-dichloro-4-[2-oxo-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-3-ylmethyl]-phenoxy}-benzamide

Base Information

Chemical Name:(R)-4-{3,5-dichloro-4-[2-oxo-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-3-ylmethyl]-phenoxy}-benzamide
CAS No.:956320-21-1
Molecular Formula:C₃₂H₄₅Cl₂N₃O₄Si
Molecular Weight:634.719
Hs Code.:

Synonyms:(R)-4-{3,5-dichloro-4-[2-oxo-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-3-ylmethyl]-phenoxy}-benzamide

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Chemical Property of (R)-4-{3,5-dichloro-4-[2-oxo-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-3-ylmethyl]-phenoxy}-benzamide

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Technology Process of (R)-4-{3,5-dichloro-4-[2-oxo-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-3-ylmethyl]-phenoxy}-benzamide

There total 10 articles about (R)-4-{3,5-dichloro-4-[2-oxo-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-3-ylmethyl]-phenoxy}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 956320-19-7
(R)-4-{3,5-dichloro-4-[2-oxo-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-3-ylmethyl]-phenoxy}-benzonitrile

: 956320-21-1
(R)-4-{3,5-dichloro-4-[2-oxo-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-3-ylmethyl]-phenoxy}-benzamide

Guidance literature:: With water; dihydrogen peroxide; potassium carbonate; In dimethyl sulfoxide; at 0 - 20 ℃; for 13.5h;

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 956320-21-1
(R)-4-{3,5-dichloro-4-[2-oxo-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-3-ylmethyl]-phenoxy}-benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetic acid; sodium nitrite / water / 5.83 h / 0 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / Heating / reflux

2.2: 0.17 h / 0 - 20 °C

3.1: sodium tris(acetoxy)borohydride / 1,1-dichloroethane / 22 h / 20 - 55 °C

4.1: hydrogen / palladium hydroxide on carbon / ethyl acetate / 4 h / 20 °C

5.1: potassium carbonate / dimethyl sulfoxide / 3 h / 80 °C

6.1: pyridine / dichloromethane / 1 h / 0 - 20 °C

7.1: water; dihydrogen peroxide; potassium carbonate / dimethyl sulfoxide / 13.5 h / 0 - 20 °C

With pyridine; lithium aluminium tetrahydride; water; hydrogen; dihydrogen peroxide; sodium tris(acetoxy)borohydride; potassium carbonate; acetic acid; sodium nitrite; palladium hydroxide on carbon; In tetrahydrofuran; 1,1-dichloroethane; dichloromethane; water; dimethyl sulfoxide; ethyl acetate;

Reference yield:

: 956320-30-2
(R)-3-(4-benzyloxy-2,6-dichloro-benzyl)-1-(4-hydroxy-piperidin-1-yl)-pyrrolidin-2-one

: 956320-21-1
(R)-4-{3,5-dichloro-4-[2-oxo-1-(4-triisopropylsilanyloxy-piperidin-1-yl)-pyrrolidin-3-ylmethyl]-phenoxy}-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium hydroxide on carbon / ethyl acetate / 4 h / 20 °C

2: potassium carbonate / dimethyl sulfoxide / 3 h / 80 °C

3: pyridine / dichloromethane / 1 h / 0 - 20 °C

4: water; dihydrogen peroxide; potassium carbonate / dimethyl sulfoxide / 13.5 h / 0 - 20 °C

With pyridine; water; hydrogen; dihydrogen peroxide; potassium carbonate; palladium hydroxide on carbon; In dichloromethane; dimethyl sulfoxide; ethyl acetate;