(S)-2-(3-Trifluoromethyl-benzylcarbamoyl)-pyrrolidine-1-carboxylic acid 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-1,1-dimethyl-undecyl ester

Base Information

• Chemical Name: (S)-2-(3-Trifluoromethyl-benzylcarbamoyl)-pyrrolidine-1-carboxylic acid 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-1,1-dimethyl-undecyl ester
• CAS No.: 350717-13-4
• Molecular Formula: C₂₇H₂₄F₂₀N₂O₃
• Molecular Weight: 804.467
• Mol file: 350717-13-4.mol

Synonyms:(S)-2-(3-Trifluoromethyl-benzylcarbamoyl)-pyrrolidine-1-carboxylic acid 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-1,1-dimethyl-undecyl ester

Chemical Property of (S)-2-(3-Trifluoromethyl-benzylcarbamoyl)-pyrrolidine-1-carboxylic acid 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-1,1-dimethyl-undecyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(3-Trifluoromethyl-benzylcarbamoyl)-pyrrolidine-1-carboxylic acid 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-1,1-dimethyl-undecyl ester

There total 5 articles about (S)-2-(3-Trifluoromethyl-benzylcarbamoyl)-pyrrolidine-1-carboxylic acid 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-1,1-dimethyl-undecyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3-(TRIFLUOROMETHYL)BENZYLAMINE (2740-83-2) + (2S)-pyrrolidine-1,2-dicarboxylic acid 1-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-1,1-dimethylundecyl) ester (350716-71-1) → (S)-2-(3-Trifluoromethyl-benzylcarbamoyl)-pyrrolidine-1-carboxylic acid 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-1,1-dimethyl-undecyl ester (350717-13-4)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In chloroform; N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1021/jo010111w

Reference yield:

2-[2-(1H,1H,2H,2H-perfluorodecyl)isopropoxycarbonyloxyimino]-2-phenylacetonitrile → (S)-2-(3-Trifluoromethyl-benzylcarbamoyl)-pyrrolidine-1-carboxylic acid 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-1,1-dimethyl-undecyl ester (350717-13-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 47 percent / Et₃N / tetrahydrofuran; H₂O / 20 °C

2: 87 percent / EDCI; HOBt; Et₃N / CHCl₃; dimethylformamide / 16 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; chloroform; water; N,N-dimethyl-formamide;

DOI:10.1021/jo010111w

Reference yield:

L-proline (147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7) → (S)-2-(3-Trifluoromethyl-benzylcarbamoyl)-pyrrolidine-1-carboxylic acid 4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-1,1-dimethyl-undecyl ester (350717-13-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 47 percent / Et₃N / tetrahydrofuran; H₂O / 20 °C

2: 87 percent / EDCI; HOBt; Et₃N / CHCl₃; dimethylformamide / 16 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; chloroform; water; N,N-dimethyl-formamide;

DOI:10.1021/jo010111w

upstream raw materials:

3-(TRIFLUOROMETHYL)BENZYLAMINE

(2S)-pyrrolidine-1,2-dicarboxylic acid 1-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoro-1,1-dimethylundecyl) ester

L-proline

5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,12-Heptadecafluoro-2-methyldodecan-2-ol

Downstream raw materials:

5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,12-Heptadecafluoro-2-methyldodecan-2-ol

Refernces