(4R,6R,7R)-4-Iodomethyl-5,8-dioxo-7-(2-phenoxy-acetylamino)-5λ⁴-thia-1-aza-bicyclo[4.2.0]octane-2,2-dicarboxylic acid dimethyl ester

Base Information

• Chemical Name: (4R,6R,7R)-4-Iodomethyl-5,8-dioxo-7-(2-phenoxy-acetylamino)-5λ⁴-thia-1-aza-bicyclo[4.2.0]octane-2,2-dicarboxylic acid dimethyl ester
• CAS No.: 380412-99-7
• Molecular Formula: C₁₉H₂₁IN₂O₈S
• Molecular Weight: 564.355

Synonyms:(4R,6R,7R)-4-Iodomethyl-5,8-dioxo-7-(2-phenoxy-acetylamino)-5λ⁴-thia-1-aza-bicyclo[4.2.0]octane-2,2-dicarboxylic acid dimethyl ester

Chemical Property of (4R,6R,7R)-4-Iodomethyl-5,8-dioxo-7-(2-phenoxy-acetylamino)-5λ⁴-thia-1-aza-bicyclo[4.2.0]octane-2,2-dicarboxylic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R,6R,7R)-4-Iodomethyl-5,8-dioxo-7-(2-phenoxy-acetylamino)-5λ⁴-thia-1-aza-bicyclo[4.2.0]octane-2,2-dicarboxylic acid dimethyl ester

There total 11 articles about (4R,6R,7R)-4-Iodomethyl-5,8-dioxo-7-(2-phenoxy-acetylamino)-5λ⁴-thia-1-aza-bicyclo[4.2.0]octane-2,2-dicarboxylic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

(4R,6R,7R)-4-Iodomethyl-8-oxo-7-(2-phenoxy-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]octane-2,2-dicarboxylic acid dimethyl ester (380412-98-6) → (4R,6R,7R)-4-Iodomethyl-5,8-dioxo-7-(2-phenoxy-acetylamino)-5λ4-thia-1-aza-bicyclo[4.2.0]octane-2,2-dicarboxylic acid dimethyl ester (380412-99-7)

Guidance literature:

With sodium periodate; In methanol; water; at 35 ℃; for 2h;

DOI:10.1139/v01-100

Reference yield:

(1R)-3-phenoxymethyl-(1rH,5cH)-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-7-one (35500-75-5) → (4R,6R,7R)-4-Iodomethyl-5,8-dioxo-7-(2-phenoxy-acetylamino)-5λ4-thia-1-aza-bicyclo[4.2.0]octane-2,2-dicarboxylic acid dimethyl ester (380412-99-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 50 percent / benzyltrimethylammonium hydroxide / dimethylformamide; methanol / -55 - 20 °C

2: 94 percent / benzyltrimethylammonium hydroxide / dimethylformamide; methanol / 2 h / 0 °C

3: 68 percent / iodine / CH₂Cl₂; H₂O / 6 h / 20 °C

4: 36 percent / sodium periodate / methanol; H₂O / 2 h / 35 °C

With sodium periodate; iodine; N-benzyl-trimethylammonium hydroxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1139/v01-100

Reference yield:

3-methyl-2-((1R)-7-oxo-3-phenoxymethyl-(1rH,5cH)-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-but-2-enoic acid methyl ester (380412-94-2) → (4R,6R,7R)-4-Iodomethyl-5,8-dioxo-7-(2-phenoxy-acetylamino)-5λ4-thia-1-aza-bicyclo[4.2.0]octane-2,2-dicarboxylic acid dimethyl ester (380412-99-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 78 percent / potassium permanganate; magnesium sulfate / H₂O; ethanol

2: 50 percent / benzyltrimethylammonium hydroxide / dimethylformamide; methanol / -55 - 20 °C

3: 94 percent / benzyltrimethylammonium hydroxide / dimethylformamide; methanol / 2 h / 0 °C

4: 68 percent / iodine / CH₂Cl₂; H₂O / 6 h / 20 °C

5: 36 percent / sodium periodate / methanol; H₂O / 2 h / 35 °C

With potassium permanganate; sodium periodate; iodine; N-benzyl-trimethylammonium hydroxide; magnesium sulfate; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1139/v01-100

upstream raw materials:

(4R,6R,7R)-4-Iodomethyl-8-oxo-7-(2-phenoxy-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]octane-2,2-dicarboxylic acid dimethyl ester

(1R)-3-phenoxymethyl-(1rH,5cH)-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-7-one

3-methyl-2-((1R)-7-oxo-3-phenoxymethyl-(1rH,5cH)-4-thia-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-but-2-enoic acid methyl ester

methyl 6β-phenoxyacetamidopenicillanate-1β-sulfoxide

Downstream raw materials:

(6R,7R)-4-Methylene-5,8-dioxo-7-(2-phenoxy-acetylamino)-5λ⁴-thia-1-aza-bicyclo[4.2.0]octane-2,2-dicarboxylic acid dimethyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 380412-99-7 (4R,6R,7R)-4-Iodomethyl-5,8-dioxo-7-(2-phenoxy-acetylamino)-5λ⁴-thia-1-aza-bicyclo[4.2.0]octane-2,2-dicarboxylic acid dimethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send