2-[3-Cyano-4-(4-nitro-phenyl)-5-oxo-4,5-dihydro-1H-indeno[1,2-b]pyridin-2-ylsulfanyl]-acetamide

Base Information

• Chemical Name: 2-[3-Cyano-4-(4-nitro-phenyl)-5-oxo-4,5-dihydro-1H-indeno[1,2-b]pyridin-2-ylsulfanyl]-acetamide
• CAS No.: 127871-10-7
• Molecular Formula: C₂₁H₁₄N₄O₄S
• Molecular Weight: 418.433

Synonyms:2-[3-Cyano-4-(4-nitro-phenyl)-5-oxo-4,5-dihydro-1H-indeno[1,2-b]pyridin-2-ylsulfanyl]-acetamide

Chemical Property of 2-[3-Cyano-4-(4-nitro-phenyl)-5-oxo-4,5-dihydro-1H-indeno[1,2-b]pyridin-2-ylsulfanyl]-acetamide

Chemical Property:

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Technology Process of 2-[3-Cyano-4-(4-nitro-phenyl)-5-oxo-4,5-dihydro-1H-indeno[1,2-b]pyridin-2-ylsulfanyl]-acetamide

There total 2 articles about 2-[3-Cyano-4-(4-nitro-phenyl)-5-oxo-4,5-dihydro-1H-indeno[1,2-b]pyridin-2-ylsulfanyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[(4S,4aR)-3-Cyano-9b-hydroxy-4-(4-nitro-phenyl)-5-oxo-4,4a,5,9b-tetrahydro-1H-indeno[1,2-b]pyridin-2-ylsulfanyl]-acetamide (127871-03-8) → 2-[3-Cyano-4-(4-nitro-phenyl)-5-oxo-4,5-dihydro-1H-indeno[1,2-b]pyridin-2-ylsulfanyl]-acetamide (127871-10-7)

Guidance literature:

With hydrogenchloride; In ethanol; for 0.0666667h; Yield given; Heating;

DOI:10.1007/BF00506858

Reference yield:

2-(4-chlorobenzylidene)-2H-indene-1,3-dione (15875-54-4) → 2-[3-Cyano-4-(4-nitro-phenyl)-5-oxo-4,5-dihydro-1H-indeno[1,2-b]pyridin-2-ylsulfanyl]-acetamide (127871-10-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) piperidine / 1) EtOH, r.t.

2: 0.2 N HCl / ethanol / 0.07 h / Heating

With piperidine; hydrogenchloride; In ethanol;

DOI:10.1007/BF00506858

Reference yield: 95.0%

2-[3-Cyano-4-(4-nitro-phenyl)-5-oxo-4,5-dihydro-1H-indeno[1,2-b]pyridin-2-ylsulfanyl]-acetamide (127871-10-7) → 3-amino-5-oxo-4-(p-nitrophenyl)-2-carbamoyl-4,10-dihydroindeno<1',2':6,5>pyrido<2,3-b>thiophene (127870-96-6)

Guidance literature:

With sodium hydroxide; In ethanol; a) reflux, 3-5 min, b) r.t., 30 min;

DOI:10.1007/BF00506858

upstream raw materials:

2-[(4S,4aR)-3-Cyano-9b-hydroxy-4-(4-nitro-phenyl)-5-oxo-4,4a,5,9b-tetrahydro-1H-indeno[1,2-b]pyridin-2-ylsulfanyl]-acetamide

2-(4-chlorobenzylidene)-2H-indene-1,3-dione

Downstream raw materials:

2-carbamoylmethylthio-5-oxo-4-(p-nitrophenyl)-3-cyanoindeno<1,2-b>pyridine

3-amino-5-oxo-4-(p-nitrophenyl)-2-carbamoyl-4,10-dihydroindeno<1',2':6,5>pyrido<2,3-b>thiophene

3-amino-5-oxo-4-(p-nitrophenyl)-2-carbamoylindeno<1',2':6,5>pyrido<2,3-b>thiophene

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