Technology Process of (3aS,7aS)-4,4,7a-trimethyloctahydro-1H-inden-1-one trisyl hydrazone
There total 10 articles about (3aS,7aS)-4,4,7a-trimethyloctahydro-1H-inden-1-one trisyl hydrazone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
trisylhydrazine; (+)-(3aS,7aS)-4,4,7a-trimethyloctahydro-1H-inden-1-one;
In
acetonitrile;
at 20 ℃;
for 0.25h;
With
tetrafluoroboric acid;
In
acetonitrile;
at 20 ℃;
DOI:10.1002/ejoc.201200134
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / -78 - 0 °C / Inert atmosphere
1.2: 16 h / -78 - 23 °C / Inert atmosphere
2.1: tetrabutyl ammonium fluoride / hexane; tetrahydrofuran / -78 - 23 °C / Inert atmosphere
3.1: n-butyllithium / hexane; tetrahydrofuran / 0.17 h / -78 - 0 °C / Inert atmosphere
3.2: 2 h / -78 - 23 °C / Inert atmosphere
4.1: tin(IV) chloride; (R)-3,3’-dichloro-1,1’-binaphthalene-2,2’-diol / dichloromethane / -78 °C / Inert atmosphere
4.2: 0 °C
5.1: tetrafluoroboric acid / acetonitrile / 14 h / 23 °C / Inert atmosphere
With
(R)-3,3’-dichloro-1,1’-binaphthalene-2,2’-diol; tetrafluoroboric acid; n-butyllithium; tetrabutyl ammonium fluoride; tin(IV) chloride;
In
tetrahydrofuran; hexane; dichloromethane; acetonitrile;
DOI:10.1021/jacs.7b13799
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 16 h / 7600.51 Torr
2.1: dimethylsulfide borane complex; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran / 0.28 h / 0 °C
2.2: 1 h / 0 - 20 °C
3.1: acetonitrile / 0.25 h / 20 °C
3.2: 20 °C
With
dimethylsulfide borane complex; palladium 10% on activated carbon; hydrogen; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole;
In
tetrahydrofuran; ethyl acetate; acetonitrile;
DOI:10.1002/ejoc.201200134
