methyl [phenyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3-(S)-3-²H-3,5-dideoxy-2-thio-D-glycero-β-D-galacto-non-2-ulopyranoside]onate

Base Information

• Chemical Name: methyl [phenyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3-(S)-3-²H-3,5-dideoxy-2-thio-D-glycero-β-D-galacto-non-2-ulopyranoside]onate
• CAS No.: 1606160-13-7
• Molecular Formula: C₂₆H₃₃NO₁₂S
• Molecular Weight: 584.606

Synonyms:methyl [phenyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3-(S)-3-²H-3,5-dideoxy-2-thio-D-glycero-β-D-galacto-non-2-ulopyranoside]onate

Chemical Property of methyl [phenyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3-(S)-3-²H-3,5-dideoxy-2-thio-D-glycero-β-D-galacto-non-2-ulopyranoside]onate

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Technology Process of methyl [phenyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3-(S)-3-²H-3,5-dideoxy-2-thio-D-glycero-β-D-galacto-non-2-ulopyranoside]onate

There total 2 articles about methyl [phenyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3-(S)-3-²H-3,5-dideoxy-2-thio-D-glycero-β-D-galacto-non-2-ulopyranoside]onate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C20H27(2)HClNO12 + thiophenol (108-98-5) → methyl [phenyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3-(S)-3-2H-3,5-dideoxy-2-thio-D-glycero-β-D-galacto-non-2-ulopyranoside]onate (1606160-13-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1021/ol500917k

Reference yield:

methyl [5-acetamido-2,4,7,8,9-penta-O-acetyl-3-(S)-3-2H-3,5-dideoxy-D-glycero-D-galacto-non-2-ulopyranos]onate → methyl [phenyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3-(S)-3-2H-3,5-dideoxy-2-thio-D-glycero-β-D-galacto-non-2-ulopyranoside]onate (1606160-13-7)

Guidance literature:

Multi-step reaction with 2 steps

1: acetyl chloride / methanol / 16 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C

With N-ethyl-N,N-diisopropylamine; acetyl chloride; In methanol; dichloromethane;

DOI:10.1021/ol500917k

Reference yield: 71.0%

trifluoroacetic acid-methyl ester (431-47-0) + methyl [phenyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3-(S)-3-2H-3,5-dideoxy-2-thio-D-glycero-β-D-galacto-non-2-ulopyranoside]onate (1606160-13-7) → methyl [phenyl 4,7,8,9-tetra-O-acetyl-3-(S)-3-2H-3,5-dideoxy-2-thio-5-trifluroacetamido-D-glycero-α-D-galacto-non-2-ulopyranoside]onate (1606160-17-1)

Guidance literature:

methyl [phenyl 5-acetamido-4,7,8,9-tetra-O-acetyl-3-(S)-3-²H-3,5-dideoxy-2-thio-D-glycero-β-D-galacto-non-2-ulopyranoside]onate; With methanesulfonic acid; In methanol; at 60 ℃; for 72h;

trifluoroacetic acid-methyl ester; With triethylamine; In methanol; at 20 ℃; for 1h; Inert atmosphere;

With acetic anhydride; In pyridine; at 20 ℃; for 16h;

DOI:10.1021/ol500917k

upstream raw materials:

thiophenol

Downstream raw materials:

methyl 5-acetamido-4,7,8,9-tetra-O-acetyl-2,6-anhydro-3,5-dideoxy-3-²H-D-glycero-D-galacto-non-2-enonate

methyl-2,3-didehydro-4,7,8,9-tetra-O-acetyl-N-acetylneuraminate

methyl [phenyl 4,7,8,9-tetra-O-acetyl-3-(S)-3-²H-3,5-dideoxy-2-thio-5-trifluroacetamido-D-glycero-α-D-galacto-non-2-ulopyranoside]onate

methyl [phenyl 7,8,9-tri-O-acetyl-5-amino-5,4-N,O-carbonyl-3-(S)-deuterio-3,5-dideoxy-2-thio-D-glycero-α-D-galacto-non-2-ulopyranoside]onate

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