tert-butyl (S)-(1-oxo-3-phenyl-1-((3-(pyridin-4-yl)isoxazol-5-yl)amino)propan-2-yl)carbamate trifluoroacetate

Base Information

• Chemical Name: tert-butyl (S)-(1-oxo-3-phenyl-1-((3-(pyridin-4-yl)isoxazol-5-yl)amino)propan-2-yl)carbamate trifluoroacetate
• CAS No.: 1240521-36-1
• Molecular Formula: C₂HF₃O₂*C₂₂H₂₄N₄O₄
• Molecular Weight: 522.481

Synonyms:tert-butyl (S)-(1-oxo-3-phenyl-1-((3-(pyridin-4-yl)isoxazol-5-yl)amino)propan-2-yl)carbamate trifluoroacetate

Chemical Property of tert-butyl (S)-(1-oxo-3-phenyl-1-((3-(pyridin-4-yl)isoxazol-5-yl)amino)propan-2-yl)carbamate trifluoroacetate

Chemical Property:

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Technology Process of tert-butyl (S)-(1-oxo-3-phenyl-1-((3-(pyridin-4-yl)isoxazol-5-yl)amino)propan-2-yl)carbamate trifluoroacetate

There total 2 articles about tert-butyl (S)-(1-oxo-3-phenyl-1-((3-(pyridin-4-yl)isoxazol-5-yl)amino)propan-2-yl)carbamate trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) + trifluoroacetic acid (76-05-1) + 3-(pyridin-4-yl)isoxazol-5-amine (19790-96-6) → tert-butyl (S)-(1-oxo-3-phenyl-1-((3-(pyridin-4-yl)isoxazol-5-yl)amino)propan-2-yl)carbamate trifluoroacetate (1240521-36-1)

Guidance literature:

N-tert-butoxycarbonyl-L-phenylalanine; 3-(pyridin-4-yl)isoxazol-5-amine; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 50 ℃; for 6h;

trifluoroacetic acid; In water; acetonitrile; for 0.75h;

DOI:10.1021/ml4000854

Reference yield:

→ tert-butyl (S)-(1-oxo-3-phenyl-1-((3-(pyridin-4-yl)isoxazol-5-yl)amino)propan-2-yl)carbamate trifluoroacetate (1240521-36-1)

Guidance literature:

Reference yield: 81.0%

tert-butyl (S)-(1-oxo-3-phenyl-1-((3-(pyridin-4-yl)isoxazol-5-yl)amino)propan-2-yl)carbamate trifluoroacetate (1240521-36-1) + trifluoroacetic acid (76-05-1) → (S)-2-amino-3-phenyl-N-(3-(pyridin-4-yl)isoxazol-5-yl)propanamide (1240521-37-2)

Guidance literature:

In dichloromethane; at 20 ℃; for 3h;

upstream raw materials:

N-tert-butoxycarbonyl-L-phenylalanine

trifluoroacetic acid

3-(pyridin-4-yl)isoxazol-5-amine

Downstream raw materials:

(S)-2-amino-3-phenyl-N-(3-(pyridin-4-yl)isoxazol-5-yl)propanamide

(S)-3-phenyl-N-(3-(pyridin-4-yl)isoxazol-5-yl)-2-(thiazol-4-ylmethylamino)propanamide

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