Technology Process of N-(tert-butyl)-3,4-dihydro-9-[4-(4-propargyloxymethyl)benzoylphenyl]-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
There total 7 articles about N-(tert-butyl)-3,4-dihydro-9-[4-(4-propargyloxymethyl)benzoylphenyl]-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C29H29N3O2S;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 0 ℃;
for 0.5h;
propargyl bromide;
In
tetrahydrofuran; mineral oil;
at 0 - 20 ℃;
DOI:10.1016/j.bmc.2013.01.016
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C
2.1: triethylamine; dmap / dichloromethane / 3 h / 20 °C
3.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.93 h / -78 °C / Inert atmosphere
3.2: 1 h / -78 - 20 °C / Inert atmosphere
4.1: tetrakis(triphenylphosphine) palladium(0); dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate / toluene; ethanol; water / 1 h / Reflux
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C
6.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
6.2: 0 - 20 °C
With
dmap; tetrakis(triphenylphosphine) palladium(0); dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; tetrabutyl ammonium fluoride; tert.-butyl lithium; sodium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil; pentane;
4.1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmc.2013.01.016
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: tetrakis(triphenylphosphine) palladium(0); dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate / toluene; ethanol; water / 1 h / Reflux
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
3.2: 0 - 20 °C
With
tetrakis(triphenylphosphine) palladium(0); dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; tetrabutyl ammonium fluoride; sodium hydride; potassium carbonate;
In
tetrahydrofuran; ethanol; water; toluene; mineral oil;
1.1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmc.2013.01.016
