(2-{2-[1-(1-benzenesulfonyl-1H-indol-3-yl)-2-trifluoroacetyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl]-1H-indol-3-yl}-ethyl)-carbamic acid benzyl ester

Base Information

Chemical Name:(2-{2-[1-(1-benzenesulfonyl-1H-indol-3-yl)-2-trifluoroacetyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl]-1H-indol-3-yl}-ethyl)-carbamic acid benzyl ester
CAS No.:615574-47-5
Molecular Formula:C₄₅H₃₆F₃N₅O₅S
Molecular Weight:815.873
Hs Code.:

(2-{2-[1-(1-benzenesulfonyl-1<i>H</i>-indol-3-yl)-2-trifluoroacetyl-2,3,4,9-tetrahydro-1<i>H</i>-β-carbolin-1-yl]-1<i>H</i>-indol-3-yl}-ethyl)-carbamic acid benzyl ester

Synonyms:(2-{2-[1-(1-benzenesulfonyl-1H-indol-3-yl)-2-trifluoroacetyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl]-1H-indol-3-yl}-ethyl)-carbamic acid benzyl ester

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Chemical Property of (2-{2-[1-(1-benzenesulfonyl-1H-indol-3-yl)-2-trifluoroacetyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl]-1H-indol-3-yl}-ethyl)-carbamic acid benzyl ester

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Technology Process of (2-{2-[1-(1-benzenesulfonyl-1H-indol-3-yl)-2-trifluoroacetyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl]-1H-indol-3-yl}-ethyl)-carbamic acid benzyl ester

There total 3 articles about (2-{2-[1-(1-benzenesulfonyl-1H-indol-3-yl)-2-trifluoroacetyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl]-1H-indol-3-yl}-ethyl)-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 407-25-0
trifluoroacetic anhydride

: [2-(2-{(1-benzenesulfonyl-1H-indol-2-yl)-[2-(1H-indol-3-yl)-ethylimino]-methyl}-1H-indol-3-yl)-ethyl]-carbamic acid benzyl ester

: 615574-47-5
(2-{2-[1-(1-benzenesulfonyl-1H-indol-3-yl)-2-trifluoroacetyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl]-1H-indol-3-yl}-ethyl)-carbamic acid benzyl ester

Guidance literature:: In dichloromethane; at 45 ℃; for 15h;
DOI:10.1055/s-2003-40836

Reference yield:

: 61-54-1
tryptamine

: 615574-47-5
(2-{2-[1-(1-benzenesulfonyl-1H-indol-3-yl)-2-trifluoroacetyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl]-1H-indol-3-yl}-ethyl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: aq. K₂CO₃ / ethyl acetate / 20 h / 20 °C

2: POCl₃ / 3 h / 80 °C

3: 42 percent / aq. Na₂CO₃ / CH₂Cl₂ / 20 h / 20 °C

4: 67 percent / ZnCl₂ / xylene / 1 h / 130 °C / microwave irradiation

5: 67 percent / CH₂Cl₂ / 15 h / 45 °C

With sodium carbonate; potassium carbonate; zinc(II) chloride; trichlorophosphate; In dichloromethane; ethyl acetate; xylene; 2: Bischler-Napieralski cyclization / 3: Schotten-Baumann reaction;
DOI:10.1055/s-2003-40836

Reference yield:

: 615574-45-3
1-benzenesulfonyl-1H-indole-3-carboxylic acid [2-(1H-indol-3-yl)-ethyl]-amide

: 615574-47-5
(2-{2-[1-(1-benzenesulfonyl-1H-indol-3-yl)-2-trifluoroacetyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl]-1H-indol-3-yl}-ethyl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: POCl₃ / 3 h / 80 °C

2: 42 percent / aq. Na₂CO₃ / CH₂Cl₂ / 20 h / 20 °C

3: 67 percent / ZnCl₂ / xylene / 1 h / 130 °C / microwave irradiation

4: 67 percent / CH₂Cl₂ / 15 h / 45 °C

With sodium carbonate; zinc(II) chloride; trichlorophosphate; In dichloromethane; xylene; 1: Bischler-Napieralski cyclization / 2: Schotten-Baumann reaction;
DOI:10.1055/s-2003-40836