(3R,7S,8aS)-6-(benzyloxycarbonyl)-8a-methyl-5-oxo-3,7-diphenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

Base Information

Chemical Name:(3R,7S,8aS)-6-(benzyloxycarbonyl)-8a-methyl-5-oxo-3,7-diphenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine
CAS No.:1049705-08-9
Molecular Formula:C₂₈H₂₇NO₄
Molecular Weight:441.527
Hs Code.:

Synonyms:(3R,7S,8aS)-6-(benzyloxycarbonyl)-8a-methyl-5-oxo-3,7-diphenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

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Chemical Property of (3R,7S,8aS)-6-(benzyloxycarbonyl)-8a-methyl-5-oxo-3,7-diphenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

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Technology Process of (3R,7S,8aS)-6-(benzyloxycarbonyl)-8a-methyl-5-oxo-3,7-diphenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

There total 1 articles about (3R,7S,8aS)-6-(benzyloxycarbonyl)-8a-methyl-5-oxo-3,7-diphenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1049705-02-3
(3R,8aS)-6-(benzyloxycarbonyl)-8a-methyl-5-oxo-3-phenyl-2,3,8,8a-tetrahydro-5H-oxazolo[3,2-a]pyridine

: phenylmagnesium bromide

: 1049705-08-9
(3R,7S,8aS)-6-(benzyloxycarbonyl)-8a-methyl-5-oxo-3,7-diphenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

: (3R,7R,8aS)-6-(benzyloxycarbonyl)-8a-methyl-5-oxo-3,7-diphenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

Guidance literature:: With copper(l) iodide; chloro-trimethyl-silane; lithium chloride; In tetrahydrofuran; at -78 ℃; for 20h;
DOI:10.1021/jo801172b

Reference yield: 68.0%

: 1049705-08-9
(3R,7S,8aS)-6-(benzyloxycarbonyl)-8a-methyl-5-oxo-3,7-diphenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

: 1049705-15-8
(3R,7S,8aS)-8a-methyl-5-oxo-3,7-diphenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine

Guidance literature:: (3R,7S,8aS)-6-(benzyloxycarbonyl)-8a-methyl-5-oxo-3,7-diphenyl-2,3,6,7,8,8a-hexahydro-5H-oxazolo[3,2-a]pyridine; With ammonium formate; palladium on activated charcoal; In methanol; at 20 ℃; for 18h;

In toluene; for 12h; Further stages.; Heating;
DOI:10.1021/jo801172b