(S)-2-[(S)-2-(tert-butoxycarbonylmethylamino)propionylamino]-3-methyl-butyric acid benzyl ester

Base Information

• Chemical Name: (S)-2-[(S)-2-(tert-butoxycarbonylmethylamino)propionylamino]-3-methyl-butyric acid benzyl ester
• CAS No.: 1599453-90-3
• Molecular Formula: C₂₁H₃₂N₂O₅
• Molecular Weight: 392.495
• Mol file: 1599453-90-3.mol

Synonyms:(S)-2-[(S)-2-(tert-butoxycarbonylmethylamino)propionylamino]-3-methyl-butyric acid benzyl ester

Chemical Property of (S)-2-[(S)-2-(tert-butoxycarbonylmethylamino)propionylamino]-3-methyl-butyric acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (S)-2-[(S)-2-(tert-butoxycarbonylmethylamino)propionylamino]-3-methyl-butyric acid benzyl ester

There total 1 articles about (S)-2-[(S)-2-(tert-butoxycarbonylmethylamino)propionylamino]-3-methyl-butyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(tert-butoxycarbonyl)-N-methyl-L-alanine (16948-16-6) + L-valine benzyl ester hydrochloride (2462-34-2) → (S)-2-[(S)-2-(tert-butoxycarbonylmethylamino)propionylamino]-3-methyl-butyric acid benzyl ester (1599453-90-3)

Guidance literature:

With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 23 ℃; for 3h;

Reference yield:

(S)-2-[(S)-2-(tert-butoxycarbonylmethylamino)propionylamino]-3-methyl-butyric acid benzyl ester (1599453-90-3) → C16H24N2O3

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃;

DOI:10.1002/anie.201706367

Reference yield:

(S)-2-[(S)-2-(tert-butoxycarbonylmethylamino)propionylamino]-3-methyl-butyric acid benzyl ester (1599453-90-3) → (S)-2-[(S)-2-(tert-butoxycarbonylmethylamino)propionylamino]-3-methylbutyric acid (876622-63-8)

Guidance literature:

With methanol; lithium hydroxide; In tetrahydrofuran; water; at 20 ℃;

upstream raw materials:

N-(tert-butoxycarbonyl)-N-methyl-L-alanine

L-valine benzyl ester hydrochloride

Downstream raw materials:

(S)-2-[(S)-2-(tert-butoxycarbonylmethylamino)propionylamino]-3-methylbutyric acid