10-Ketonaltrexone

Base Information

Chemical Name:10-Ketonaltrexone
CAS No.:96445-14-6
Molecular Formula:C₂₀H₂₁NO₅
Molecular Weight:355.39
Hs Code.:
European Community (EC) Number:804-569-3
UNII:BFV7ALA2A9
DSSTox Substance ID:DTXSID30914505
Wikidata:Q76309594
Mol file:96445-14-6.mol

Synonyms:10-ketonaltrexone

Suppliers and Price of 10-Ketonaltrexone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
10-Ketonaltrexone solution 100?μg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
1 mL
$ 523.00

Sigma-Aldrich
10-Ketonaltrexone solution 100μg/mL in methanol, ampule of 1mL, certified reference material
007-03-1ml
$ 507.00

American Custom Chemicals Corporation
10-KETONALTREXONE 95.00%
5MG
$ 499.73

Total 6 raw suppliers

Chemical Property of 10-Ketonaltrexone

Chemical Property:

Vapor Pressure:6.31E-17mmHg at 25°C
Melting Point:160-165°C
Boiling Point:633.6°Cat760mmHg
Flash Point:337°C
PSA：87.07000
Density:1.56g/cm³
LogP:1.10350
Storage Temp.:-20°C Freezer
XLogP3:1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:355.14197277
Heavy Atom Count:26
Complexity:692

Purity/Quality:

99.0% Min ^*data from raw suppliers

10-Ketonaltrexone solution 100?μg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant? ^*data from reagent suppliers

Safty Information:

Pictogram(s): F,T
Hazard Codes:F,T
Statements: 11-23/24/25-39/23/24/25
Safety Statements: 7-16-36/37-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC1CN2CCC34C5C(=O)CCC3(C2C(=O)C6=C4C(=C(C=C6)O)O5)O
Isomeric SMILES:C1CC1CN2CC[C@]34[C@@H]5C(=O)CC[C@]3([C@H]2C(=O)C6=C4C(=C(C=C6)O)O5)O
Uses Naltrexone

Technology Process of 10-Ketonaltrexone

There total 3 articles about 10-Ketonaltrexone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 96445-13-5
17-(cyclopropylmethyl)-4,5α-epoxy-14β-hydroxy-3-methoxymorphinan-6,10-dione

: 96445-14-6
10-Ketonaltrexone

Guidance literature:: With boron tribromide; In chloroform; for 43h; Ambient temperature;
DOI:10.1021/jm00145a024

Reference yield:

: 16617-07-5
naltrexone methyl ether

: 96445-14-6
10-Ketonaltrexone

Guidance literature:: Multi-step reaction with 3 steps

1: 4.6 percent / CrO₃, conc. H₂SO₄ / 28 h / 25 °C

2: 9.2 mg / CrO₃-DMP complex / CH₂Cl₂ / 0.25 h

3: 38 percent / BBr₃ / CHCl₃ / 43 h / Ambient temperature

With chromium(VI) oxide; CrO₃-DMP; sulfuric acid; boron tribromide; In dichloromethane; chloroform;
DOI:10.1021/jm00145a024

Reference yield:

: 96445-12-4
10-hydroxynaltrexone 3-methyl ether

: 96445-14-6
10-Ketonaltrexone

Guidance literature:: Multi-step reaction with 2 steps

1: 9.2 mg / CrO₃-DMP complex / CH₂Cl₂ / 0.25 h

2: 38 percent / BBr₃ / CHCl₃ / 43 h / Ambient temperature

With CrO₃-DMP; boron tribromide; In dichloromethane; chloroform;
DOI:10.1021/jm00145a024