6-chloro-4'-[5-(2-chloro-5-cyanophenyl)benzofuran-2-carbonyl]biphenyl-3-carbonitrile

Base Information

Chemical Name:6-chloro-4'-[5-(2-chloro-5-cyanophenyl)benzofuran-2-carbonyl]biphenyl-3-carbonitrile
CAS No.:1370016-07-1
Molecular Formula:C₂₉H₁₄Cl₂N₂O₂
Molecular Weight:493.348
Hs Code.:

Synonyms:6-chloro-4'-[5-(2-chloro-5-cyanophenyl)benzofuran-2-carbonyl]biphenyl-3-carbonitrile

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Chemical Property of 6-chloro-4'-[5-(2-chloro-5-cyanophenyl)benzofuran-2-carbonyl]biphenyl-3-carbonitrile

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Technology Process of 6-chloro-4'-[5-(2-chloro-5-cyanophenyl)benzofuran-2-carbonyl]biphenyl-3-carbonitrile

There total 3 articles about 6-chloro-4'-[5-(2-chloro-5-cyanophenyl)benzofuran-2-carbonyl]biphenyl-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 936249-33-1
(2-chloro-5-cyanophenyl)boronic acid

: 83806-46-6
(5-bromo-1-benzofuran-2-yl)(4-bromophenyl)methanone

: 1370016-07-1
6-chloro-4'-[5-(2-chloro-5-cyanophenyl)benzofuran-2-carbonyl]biphenyl-3-carbonitrile

Guidance literature:: (2-chloro-5-cyanophenyl)boronic acid; (5-bromo-1-benzofuran-2-yl)(4-bromophenyl)methanone; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; toluene; at 110 ℃; for 5h; Inert atmosphere;

With dihydrogen peroxide; In ethanol; water; toluene; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1007/s00044-012-0017-y

Reference yield:

: 99-73-0,132309-76-3
para-bromophenacyl bromide

: 1370016-07-1
6-chloro-4'-[5-(2-chloro-5-cyanophenyl)benzofuran-2-carbonyl]biphenyl-3-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; sodium carbonate / water / 5 h / 80 °C

2.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene; ethanol / 5 h / 110 °C / Inert atmosphere

2.2: 1 h / 20 °C / Inert atmosphere

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; toluene; 2.1: |Suzuki Coupling;
DOI:10.1007/s00044-012-0017-y

Reference yield:

: 1761-61-1
5-bromosalicyclaldehyde

: 1370016-07-1
6-chloro-4'-[5-(2-chloro-5-cyanophenyl)benzofuran-2-carbonyl]biphenyl-3-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap; sodium carbonate / water / 5 h / 80 °C

2.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene; ethanol / 5 h / 110 °C / Inert atmosphere

2.2: 1 h / 20 °C / Inert atmosphere

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; toluene; 2.1: |Suzuki Coupling;
DOI:10.1007/s00044-012-0017-y