1-((5-(([1,1'-biphenyl]-2-yloxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)-3-(pyrazin-2-yl)urea

Base Information

Chemical Name:1-((5-(([1,1'-biphenyl]-2-yloxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)-3-(pyrazin-2-yl)urea
CAS No.:1620290-36-9
Molecular Formula:C₂₂H₂₁N₅O₃
Molecular Weight:403.44
Hs Code.:

Synonyms:1-((5-(([1,1'-biphenyl]-2-yloxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)-3-(pyrazin-2-yl)urea

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Chemical Property of 1-((5-(([1,1'-biphenyl]-2-yloxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)-3-(pyrazin-2-yl)urea

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Technology Process of 1-((5-(([1,1'-biphenyl]-2-yloxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)-3-(pyrazin-2-yl)urea

There total 4 articles about 1-((5-(([1,1'-biphenyl]-2-yloxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)-3-(pyrazin-2-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.0%

: 98-97-5
2-pyrazylcarboxylic acid

: 1620292-15-0
(5-(([1,1'-biphenyl]-2-yloxy)methyl)-4,5-dihydroisoxazol-3-yl)methanamine hydrochloride

: 1620290-36-9
1-((5-(([1,1'-biphenyl]-2-yloxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)-3-(pyrazin-2-yl)urea

Guidance literature:: 2-pyrazylcarboxylic acid; With diphenyl phosphoryl azide; triethylamine; at 20 - 110 ℃; for 1h;

(5-(([1,1'-biphenyl]-2-yloxy)methyl)-4,5-dihydroisoxazol-3-yl)methanamine hydrochloride; at 20 ℃; for 16h;

Reference yield:

: 90-43-7,287950-96-3
2-Phenylphenol

: 1620290-36-9
1-((5-(([1,1'-biphenyl]-2-yloxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)-3-(pyrazin-2-yl)urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 70 °C

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 20 °C

2.2: 36.5 h / 0 - 20 °C

3.1: hydrogenchloride / 1,4-dioxane / 12 h / 0 - 20 °C

4.1: triethylamine; diphenyl phosphoryl azide / 1 h / 20 - 110 °C

4.2: 16 h / 20 °C

With hydrogenchloride; N-chloro-succinimide; diphenyl phosphoryl azide; potassium carbonate; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;

Reference yield:

: 20281-39-4
2-(allyloxy)-1,1'-biphenyl

: 1620290-36-9
1-((5-(([1,1'-biphenyl]-2-yloxy)methyl)-4,5-dihydroisoxazol-3-yl)methyl)-3-(pyrazin-2-yl)urea

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 3 h / 20 °C

1.2: 36.5 h / 0 - 20 °C

2.1: hydrogenchloride / 1,4-dioxane / 12 h / 0 - 20 °C

3.1: triethylamine; diphenyl phosphoryl azide / 1 h / 20 - 110 °C

3.2: 16 h / 20 °C

With hydrogenchloride; N-chloro-succinimide; diphenyl phosphoryl azide; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;