2-[(R)-1-[(S)-2-(Cyclohexyl-methyl-carbamoyloxy)-4-methyl-pentanoylamino]-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-oxazole-4-carboxylic acid benzyl ester

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Chemical Name:2-[(R)-1-[(S)-2-(Cyclohexyl-methyl-carbamoyloxy)-4-methyl-pentanoylamino]-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-oxazole-4-carboxylic acid benzyl ester
CAS No.:179169-21-2
Molecular Formula:C₃₇H₄₆N₄O₆
Molecular Weight:642.795
Hs Code.:

2-[(R)-1-[(S)-2-(Cyclohexyl-methyl-carbamoyloxy)-4-methyl-pentanoylamino]-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-oxazole-4-carboxylic acid benzyl ester

Synonyms:2-[(R)-1-[(S)-2-(Cyclohexyl-methyl-carbamoyloxy)-4-methyl-pentanoylamino]-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-oxazole-4-carboxylic acid benzyl ester

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Chemical Property of 2-[(R)-1-[(S)-2-(Cyclohexyl-methyl-carbamoyloxy)-4-methyl-pentanoylamino]-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-oxazole-4-carboxylic acid benzyl ester

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Technology Process of 2-[(R)-1-[(S)-2-(Cyclohexyl-methyl-carbamoyloxy)-4-methyl-pentanoylamino]-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-oxazole-4-carboxylic acid benzyl ester

There total 6 articles about 2-[(R)-1-[(S)-2-(Cyclohexyl-methyl-carbamoyloxy)-4-methyl-pentanoylamino]-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-oxazole-4-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13748-90-8,498-36-2
(S)-2-hydroxyl-3,3-dimethylbutyric acid

: 179169-21-2
2-[(R)-1-[(S)-2-(Cyclohexyl-methyl-carbamoyloxy)-4-methyl-pentanoylamino]-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-oxazole-4-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Cs₂CO₃, Na₂CO₃ / 1.) THF, 20 min, 2.) THF, DMF, a) RT, 15 h, b) 40 deg C, 3 h

2: tetrahydrofuran / 6 h / Ambient temperature

3: 1.) methyl trifluoromethanesulfonate / 1.) THF, 0 deg C, 30 min, 2.) THF, RT, 12 h

4: H₂ / 10percent Pd/C / ethanol / 4 h / Ambient temperature

5: 1-hydroxybenzotriazole hydrate, 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrochloride, N-methylmorpholine / tetrahydrofuran / 18 h / Ambient temperature

With 4-methyl-morpholine; hydrogen; sodium carbonate; caesium carbonate; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; methyl trifluoromethanesulfonate; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/jm9505932

Reference yield:

: 37755-48-9,40298-04-2
benzyl (2S)-2-hydroxy-4-methylpentanoate

: 179169-21-2
2-[(R)-1-[(S)-2-(Cyclohexyl-methyl-carbamoyloxy)-4-methyl-pentanoylamino]-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-oxazole-4-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: tetrahydrofuran / 6 h / Ambient temperature

2: 1.) methyl trifluoromethanesulfonate / 1.) THF, 0 deg C, 30 min, 2.) THF, RT, 12 h

3: H₂ / 10percent Pd/C / ethanol / 4 h / Ambient temperature

4: 1-hydroxybenzotriazole hydrate, 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrochloride, N-methylmorpholine / tetrahydrofuran / 18 h / Ambient temperature

With 4-methyl-morpholine; hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; methyl trifluoromethanesulfonate; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/jm9505932

Reference yield:

: 179169-20-1
Imidazole-1-carboxylic acid (S)-1-benzyloxycarbonyl-3-methyl-butyl ester

: 179169-21-2
2-[(R)-1-[(S)-2-(Cyclohexyl-methyl-carbamoyloxy)-4-methyl-pentanoylamino]-2-(1-methyl-1H-indol-3-yl)-ethyl]-5-methyl-oxazole-4-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) methyl trifluoromethanesulfonate / 1.) THF, 0 deg C, 30 min, 2.) THF, RT, 12 h

2: H₂ / 10percent Pd/C / ethanol / 4 h / Ambient temperature

3: 1-hydroxybenzotriazole hydrate, 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrochloride, N-methylmorpholine / tetrahydrofuran / 18 h / Ambient temperature

With 4-methyl-morpholine; hydrogen; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; methyl trifluoromethanesulfonate; palladium on activated charcoal; In tetrahydrofuran; ethanol;
DOI:10.1021/jm9505932