C₃₈H₃₅F₂N₅O₄S

Base Information

• Chemical Name: C₃₈H₃₅F₂N₅O₄S
• CAS No.: 481049-99-4
• Molecular Formula: C₃₈H₃₅F₂N₅O₄S
• Molecular Weight: 695.79
• Mol file: 481049-99-4.mol

Synonyms:C₃₈H₃₅F₂N₅O₄S

Chemical Property of C₃₈H₃₅F₂N₅O₄S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₈H₃₅F₂N₅O₄S

There total 10 articles about C₃₈H₃₅F₂N₅O₄S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-difluorobenzyl chloride (697-73-4) → C38H35F2N5O4S (481049-99-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 90 percent / KI; K₂CO₃ / dimethylformamide / 4 h / 20 °C

2.1: NBS; AIBN / chlorobenzene / 1.5 h / 90 °C

3.1: 33.0 g / i-Pr₂NEt / dimethylformamide / 2 h / 20 °C

4.1: 87 percent / HCl; HCO₂H / 10 percent Pd/C/water / diethyl ether / 3.5 h / 20 °C / atmospheric pressure

5.1: Et₃N / CH₂Cl₂ / 20 °C

5.2: Et₃N / CH₂Cl₂ / 20 °C

With hydrogenchloride; N-Bromosuccinimide; formic acid; 2,2'-azobis(isobutyronitrile); potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; potassium iodide; 10 percent Pd/C/water; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; chlorobenzene;

DOI:10.1021/jm020180i

Reference yield:

1-(4-nitrophenyl)propan-2-one (5332-96-7) → C38H35F2N5O4S (481049-99-4)

Guidance literature:

Multi-step reaction with 8 steps

1.1: NH₄OAc; AcOH / toluene / 20 h / Heating

1.2: 67 percent / sulfur / ethanol / 2 h / 65 °C

2.1: pyridine / 2 h / 45 °C

3.1: 50.4 g / NaOMe / methanol / 6 h / 20 °C

4.1: 90 percent / KI; K₂CO₃ / dimethylformamide / 4 h / 20 °C

5.1: NBS; AIBN / chlorobenzene / 1.5 h / 90 °C

6.1: 33.0 g / i-Pr₂NEt / dimethylformamide / 2 h / 20 °C

7.1: 87 percent / HCl; HCO₂H / 10 percent Pd/C/water / diethyl ether / 3.5 h / 20 °C / atmospheric pressure

8.1: Et₃N / CH₂Cl₂ / 20 °C

8.2: Et₃N / CH₂Cl₂ / 20 °C

With pyridine; hydrogenchloride; N-Bromosuccinimide; formic acid; 2,2'-azobis(isobutyronitrile); ammonium acetate; sodium methylate; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; potassium iodide; 10 percent Pd/C/water; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; chlorobenzene; toluene;

DOI:10.1021/jm020180i

Reference yield:

phenyl isocyanate (103-71-9) → C38H35F2N5O4S (481049-99-4)

Guidance literature:

Multi-step reaction with 7 steps

1.1: pyridine / 2 h / 45 °C

2.1: 50.4 g / NaOMe / methanol / 6 h / 20 °C

3.1: 90 percent / KI; K₂CO₃ / dimethylformamide / 4 h / 20 °C

4.1: NBS; AIBN / chlorobenzene / 1.5 h / 90 °C

5.1: 33.0 g / i-Pr₂NEt / dimethylformamide / 2 h / 20 °C

6.1: 87 percent / HCl; HCO₂H / 10 percent Pd/C/water / diethyl ether / 3.5 h / 20 °C / atmospheric pressure

7.1: Et₃N / CH₂Cl₂ / 20 °C

7.2: Et₃N / CH₂Cl₂ / 20 °C

With pyridine; hydrogenchloride; N-Bromosuccinimide; formic acid; 2,2'-azobis(isobutyronitrile); sodium methylate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; potassium iodide; 10 percent Pd/C/water; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; chlorobenzene;

DOI:10.1021/jm020180i

upstream raw materials:

isopropoxyamine hydrochloride

1,1'-carbonyldiimidazole

6-(4-aminophenyl)-5-(N-benzyl-N-methylaminomethyl)-1-(2,6-difluorobenzyl)-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione

1-(4-nitrophenyl)propan-2-one