(3R,5R)-3-[1-methyl-1-(6-trifluoromethyl-pyridin-3-yl)-ethylamino]-1-(4-trifluoromethyl-phenyl)-5-(3-trifluoromethoxy-phenyl)-pyrrolidin-2-one

Base Information

Chemical Name:(3R,5R)-3-[1-methyl-1-(6-trifluoromethyl-pyridin-3-yl)-ethylamino]-1-(4-trifluoromethyl-phenyl)-5-(3-trifluoromethoxy-phenyl)-pyrrolidin-2-one
CAS No.:1031721-36-4
Molecular Formula:C₂₇H₂₂F₉N₃O₂
Molecular Weight:591.476
Hs Code.:

Synonyms:(3R,5R)-3-[1-methyl-1-(6-trifluoromethyl-pyridin-3-yl)-ethylamino]-1-(4-trifluoromethyl-phenyl)-5-(3-trifluoromethoxy-phenyl)-pyrrolidin-2-one

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Chemical Property of (3R,5R)-3-[1-methyl-1-(6-trifluoromethyl-pyridin-3-yl)-ethylamino]-1-(4-trifluoromethyl-phenyl)-5-(3-trifluoromethoxy-phenyl)-pyrrolidin-2-one

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Technology Process of (3R,5R)-3-[1-methyl-1-(6-trifluoromethyl-pyridin-3-yl)-ethylamino]-1-(4-trifluoromethyl-phenyl)-5-(3-trifluoromethoxy-phenyl)-pyrrolidin-2-one

There total 3 articles about (3R,5R)-3-[1-methyl-1-(6-trifluoromethyl-pyridin-3-yl)-ethylamino]-1-(4-trifluoromethyl-phenyl)-5-(3-trifluoromethoxy-phenyl)-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: (R)-3-[1-methyl-1-(6-trifluoromethyl-pyridin-3-yl)-ethylamino]-5-(3-trifluoromethoxy-phenyl)-1-(4-trifluoromethyl-phenyl)-1,5-dihydro-pyrrol-2-one

: 1031721-36-4
(3R,5R)-3-[1-methyl-1-(6-trifluoromethyl-pyridin-3-yl)-ethylamino]-1-(4-trifluoromethyl-phenyl)-5-(3-trifluoromethoxy-phenyl)-pyrrolidin-2-one

: 1031721-39-7
(3S,5R)-3-[1-methyl-1-(6-trifluoromethyl-pyridin-3-yl)-ethylamino]-1-(4-trifluoromethyl-phenyl)-5-(3-trifluoromethoxy-phenyl)-pyrrolidin-2-one

Guidance literature:: With sodium cyanoborohydride; acetic acid; at 20 ℃; for 1.75h;

Reference yield:

: 1031721-37-5
(3R,5R)-3-[1-methyl-1-(6-trifluoromethyl-pyridin-3-yl)-ethylamino]-1-(4-trifluoromethyl-phenyl)-5-(3-trifluoromethoxy-phenyl)-pyrrolidin-2-one, 4-methylbenzenesulfonate

: 1031721-36-4
(3R,5R)-3-[1-methyl-1-(6-trifluoromethyl-pyridin-3-yl)-ethylamino]-1-(4-trifluoromethyl-phenyl)-5-(3-trifluoromethoxy-phenyl)-pyrrolidin-2-one

Guidance literature:: With sodium carbonate; In water; toluene; at 20 ℃; for 1h; Product distribution / selectivity;

Reference yield:

: 1031721-46-6
1-methyl-1-(6-trifluoromethyl-pyridin-3-yl)-ethylamine hydrochloride

: (5R)-5-[3-trifluoromethoxy-phenyl]-1-(4-trifluoromethyl-phenyl)-pyrrolidine-2,3-dione

: 1031721-36-4
(3R,5R)-3-[1-methyl-1-(6-trifluoromethyl-pyridin-3-yl)-ethylamino]-1-(4-trifluoromethyl-phenyl)-5-(3-trifluoromethoxy-phenyl)-pyrrolidin-2-one

Guidance literature:: 1-methyl-1-(6-trifluoromethyl-pyridin-3-yl)-ethylamine hydrochloride; With sodium hydroxide; In water; toluene; at 20 ℃; for 0.5h;

(5R)-5-[3-trifluoromethoxy-phenyl]-1-(4-trifluoromethyl-phenyl)-pyrrolidine-2,3-dione; With acetic acid; In water; toluene; at 23 - 45 ℃; for 14 - 18h;

With sodium tris(acetoxy)borohydride; trifluoroacetic acid; In water; toluene; at 20 - 35 ℃; for 2 - 4h; Product distribution / selectivity;