(S)-N-<5-aminomethyl-3-(4-acetylphenyl)-2-oxooxazolidine>hydrochloride

Base Information

Chemical Name:(S)-N-<5-aminomethyl-3-(4-acetylphenyl)-2-oxooxazolidine>hydrochloride
CAS No.:114992-59-5
Molecular Formula:C₁₂H₁₄N₂O₃*ClH
Molecular Weight:270.716
Hs Code.:

Synonyms:(S)-N-<5-aminomethyl-3-(4-acetylphenyl)-2-oxooxazolidine>hydrochloride

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Chemical Property of (S)-N-<5-aminomethyl-3-(4-acetylphenyl)-2-oxooxazolidine>hydrochloride

Chemical Property:

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Technology Process of (S)-N-<5-aminomethyl-3-(4-acetylphenyl)-2-oxooxazolidine>hydrochloride

There total 7 articles about (S)-N-<5-aminomethyl-3-(4-acetylphenyl)-2-oxooxazolidine>hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 114992-53-9
(R)-N-<3-(4-acetylphenyl)-2-oxo-5-oxazolidinylmethyl>azide

: 114992-59-5
(S)-N-<5-aminomethyl-3-(4-acetylphenyl)-2-oxooxazolidine>hydrochloride

Guidance literature:: With phosphorous acid trimethyl ester; In 1,2-dimethoxyethane; for 1.5h; Heating;
DOI:10.1021/jm00128a003

Reference yield:

: 49647-20-3
4-acetylphenyl isocyanate

: 114992-59-5
(S)-N-<5-aminomethyl-3-(4-acetylphenyl)-2-oxooxazolidine>hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: 82 percent / LiBr, n-Bu₃PO / xylene / 2 h / Heating

2: 100 percent / sodium methoxide / methanol / 2 h / Ambient temperature

3: 96 percent / pyridine / 15 °C

4: 94 percent / NaI / acetone / 18 h / Heating

5: 70 percent / Et₃N / tetrahydrofuran / 18 h / Heating

6: 87 percent / sodium azide, 18-crown-6 / dimethylformamide / 5 h / 70 °C

7: 82 percent / trimethyl phosphite / 1,2-dimethoxy-ethane / 1.5 h / Heating

With pyridine; sodium azide; 18-crown-6 ether; Tributylphosphine oxide; sodium methylate; triethylamine; sodium iodide; lithium bromide; phosphorous acid trimethyl ester; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; N,N-dimethyl-formamide; acetone; xylene;
DOI:10.1021/jm00128a003

Reference yield:

: 121372-92-7
(R)-N-<3-(4-acetylphenyl)-2-oxo-5-oxazolidinylmethyl>butyrate

: 114992-59-5
(S)-N-<5-aminomethyl-3-(4-acetylphenyl)-2-oxooxazolidine>hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / sodium methoxide / methanol / 2 h / Ambient temperature

2: 96 percent / pyridine / 15 °C

3: 94 percent / NaI / acetone / 18 h / Heating

4: 70 percent / Et₃N / tetrahydrofuran / 18 h / Heating

5: 87 percent / sodium azide, 18-crown-6 / dimethylformamide / 5 h / 70 °C

6: 82 percent / trimethyl phosphite / 1,2-dimethoxy-ethane / 1.5 h / Heating

With pyridine; sodium azide; 18-crown-6 ether; sodium methylate; triethylamine; sodium iodide; phosphorous acid trimethyl ester; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00128a003