1-(5-((4-((4-cyanobenzyl)oxy)phenyl)ethynyl)pyridin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl) propan-2-yl dihydrogen phosphate

Base Information

Chemical Name:1-(5-((4-((4-cyanobenzyl)oxy)phenyl)ethynyl)pyridin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl) propan-2-yl dihydrogen phosphate
CAS No.:1443427-35-7
Molecular Formula:C₃₁H₂₁F₄N₆O₅P
Molecular Weight:664.512
Hs Code.:

Synonyms:1-(5-((4-((4-cyanobenzyl)oxy)phenyl)ethynyl)pyridin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl) propan-2-yl dihydrogen phosphate

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Chemical Property of 1-(5-((4-((4-cyanobenzyl)oxy)phenyl)ethynyl)pyridin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl) propan-2-yl dihydrogen phosphate

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Technology Process of 1-(5-((4-((4-cyanobenzyl)oxy)phenyl)ethynyl)pyridin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl) propan-2-yl dihydrogen phosphate

There total 13 articles about 1-(5-((4-((4-cyanobenzyl)oxy)phenyl)ethynyl)pyridin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl) propan-2-yl dihydrogen phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.6%

: C₃₅H₂₅F₄N₆O₅P

: 1443427-35-7
1-(5-((4-((4-cyanobenzyl)oxy)phenyl)ethynyl)pyridin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl) propan-2-yl dihydrogen phosphate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; acetic acid; triethylamine; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 16h;

Reference yield:

: 294182-28-8
5-bromo-2-((-2-(2,4-difluorophenyl)oxiran-2-yl)difluoromethyl)pyridine

: 1443427-35-7
1-(5-((4-((4-cyanobenzyl)oxy)phenyl)ethynyl)pyridin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl) propan-2-yl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 8 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

3.1: n-butyllithium / diethyl ether; hexane / 0.5 h / -78 °C / Inert atmosphere

3.2: -78 - 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere

5.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 65 °C / Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine / hexane; ethanol / Resolution of racemate

7.1: 1H-tetrazole / dichloromethane / 2 h / 20 °C

7.2: -5 °C

8.1: acetic acid; triphenylphosphine; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 16 h / 0 - 20 °C

With 1H-tetrazole; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; tetrabutyl ammonium fluoride; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1443429-25-1
2-((2-(2,4-difluorophenyl)oxiran-2-yl)difluoromethyl)-5-((trimethylsilyl)ethynyl)pyridine

: 1443427-35-7
1-(5-((4-((4-cyanobenzyl)oxy)phenyl)ethynyl)pyridin-2-yl)-2-(2,4-difluorophenyl)-1,1-difluoro-3-(1H-tetrazol-1-yl) propan-2-yl dihydrogen phosphate

Guidance literature:: Multi-step reaction with 7 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2.1: n-butyllithium / diethyl ether; hexane / 0.5 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere

4.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 65 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / hexane; ethanol / Resolution of racemate

6.1: 1H-tetrazole / dichloromethane / 2 h / 20 °C

6.2: -5 °C

7.1: acetic acid; triphenylphosphine; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 16 h / 0 - 20 °C

With 1H-tetrazole; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; tetrabutyl ammonium fluoride; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;