2-tert-butoxycarbonylamino-4-oxo-hexanedioic acid 1-benzyl ester 6-(2-trimethylsilanyl-ethyl) ester

Base Information

• Chemical Name: 2-tert-butoxycarbonylamino-4-oxo-hexanedioic acid 1-benzyl ester 6-(2-trimethylsilanyl-ethyl) ester
• CAS No.: 766514-48-1
• Molecular Formula: C₂₃H₃₅NO₇Si
• Molecular Weight: 465.619
• Mol file: 766514-48-1.mol

Synonyms:2-tert-butoxycarbonylamino-4-oxo-hexanedioic acid 1-benzyl ester 6-(2-trimethylsilanyl-ethyl) ester

Chemical Property of 2-tert-butoxycarbonylamino-4-oxo-hexanedioic acid 1-benzyl ester 6-(2-trimethylsilanyl-ethyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-tert-butoxycarbonylamino-4-oxo-hexanedioic acid 1-benzyl ester 6-(2-trimethylsilanyl-ethyl) ester

There total 1 articles about 2-tert-butoxycarbonylamino-4-oxo-hexanedioic acid 1-benzyl ester 6-(2-trimethylsilanyl-ethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-(Trimethylsilyl)ethanol (2916-68-9) + 2-tert-butoxycarbonylamino-4-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidene)-4-hydroxy-butyric acid benzyl ester (844644-72-0) → 2-tert-butoxycarbonylamino-4-oxo-hexanedioic acid 1-benzyl ester 6-(2-trimethylsilanyl-ethyl) ester (766514-48-1)

Guidance literature:

In benzene; Heating;

DOI:10.1021/jo049441h

Reference yield: 40.0%

2-tert-butoxycarbonylamino-4-oxo-hexanedioic acid 1-benzyl ester 6-(2-trimethylsilanyl-ethyl) ester (766514-48-1) + 1,2-dideoxy-3,6-di-O-triisopropylsilyl-2-deoxy-D-arabino-1-hexenopyranose (343338-29-4) → (4aR,6R,7R,8S,8aR)-3-((S)-2-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-7-hydroxy-8-triisopropylsilanyloxy-6-triisopropylsilanyloxymethyl-6,7,8,8a-tetrahydro-4aH-4,5-dioxa-1-thia-naphthalene-2-carboxylic acid 2-trimethylsilanyl-ethyl ester (766514-63-0)

Guidance literature:

With pyridine; phthalimidesulfenyl chloride; In chloroform; at 50 - 55 ℃; for 40h;

DOI:10.1021/jo049441h

Reference yield: 35.0%

2-tert-butoxycarbonylamino-4-oxo-hexanedioic acid 1-benzyl ester 6-(2-trimethylsilanyl-ethyl) ester (766514-48-1) + 3,4,6-tri-O-benzyl-D-glucal (55628-54-1) → 1-O-2-S-[1'-trimethylsilylethoxycarbonyl-2'-(4'-t-butoxycarbonylamino)-benzylpropionate-1'-2'-ethenyl]-3,4,6-di-O-benzyl-α-D-glucopyranoside (766514-52-7)

Guidance literature:

With pyridine; phthalimidesulfenyl chloride; In chloroform; at 40 ℃;

DOI:10.1021/jo049441h

upstream raw materials:

2-(Trimethylsilyl)ethanol

2-tert-butoxycarbonylamino-4-(2,2-dimethyl-4,6-dioxo-[1,3]dioxan-5-ylidene)-4-hydroxy-butyric acid benzyl ester

Downstream raw materials:

1-O-2-S-[1'-trimethylsilylethoxycarbonyl-2'-(4'-t-butoxycarbonylamino)-benzylpropionate-1'-2'-ethenyl]-3,4,6-di-O-benzyl-α-D-glucopyranoside

(4aR,6R,7R,8S,8aR)-3-((S)-2-Benzyloxycarbonyl-2-tert-butoxycarbonylamino-ethyl)-7-hydroxy-8-triisopropylsilanyloxy-6-triisopropylsilanyloxymethyl-6,7,8,8a-tetrahydro-4aH-4,5-dioxa-1-thia-naphthalene-2-carboxylic acid 2-trimethylsilanyl-ethyl ester

(4aR,6R,7S,8S,8aR)-3-[(S)-2-Benzyloxycarbonyl-2-(2-naphthalen-2-yl-acetylamino)-ethyl]-7,8-dihydroxy-6-hydroxymethyl-6,7,8,8a-tetrahydro-4aH-4,5-dioxa-1-thia-naphthalene-2-carboxylic acid

(4aR,6R,7S,8S,8aR)-3-[(S)-2-Benzyloxycarbonyl-2-(2-biphenyl-4-yl-acetylamino)-ethyl]-7,8-dihydroxy-6-hydroxymethyl-6,7,8,8a-tetrahydro-4aH-4,5-dioxa-1-thia-naphthalene-2-carboxylic acid