2-methylene-5-phenylvaleric acid chloride

Base Information

• Chemical Name: 2-methylene-5-phenylvaleric acid chloride
• CAS No.: 78574-19-3
• Molecular Formula: C₁₂H₁₃ClO
• Molecular Weight: 208.688
• Mol file: 78574-19-3.mol

Synonyms:2-methylene-5-phenylvaleric acid chloride

Chemical Property of 2-methylene-5-phenylvaleric acid chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methylene-5-phenylvaleric acid chloride

There total 5 articles about 2-methylene-5-phenylvaleric acid chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methylene-5-phenylpentanoic acid (78574-20-6) → 2-methylene-5-phenylvaleric acid chloride (78574-19-3)

Guidance literature:

With thionyl chloride; at 50 ℃; for 7h;

DOI:10.1021/jm00344a003

Reference yield:

ethyl 2-methylene-5-phenylpentanoate (27356-88-3) → 2-methylene-5-phenylvaleric acid chloride (78574-19-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / 2 N NaOH / ethanol / 3 h / 50 °C

2: SOCl₂ / 7 h / 50 °C

With sodium hydroxide; thionyl chloride; In ethanol;

DOI:10.1021/jm00344a003

Reference yield:

diethyl 2-(3-phenylpropyl)malonate (26395-09-5) → 2-methylene-5-phenylvaleric acid chloride (78574-19-3)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium hydroxide; water / ethanol / 5 h / 120 °C

2: diethylamine; formaldehyd / ethyl acetate / 12.5 h / 0 - 85 °C

3: phosgene / dichloromethane; N,N-dimethyl-formamide / 2 h / 0 °C

With phosgene; formaldehyd; water; diethylamine; sodium hydroxide; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1039/d1cc04996h

upstream raw materials:

2-methylene-5-phenylpentanoic acid

ethyl 2-methylene-5-phenylpentanoate

3-phenylpropylmalonic acid

diethyl 2-(3-phenylpropyl)malonate

Downstream raw materials:

N-ethyl-2-methylene-5-phenylpentanamide

N,N-diethyl-2-methylene-5-phenylpentanamide

2-methylene-5-phenylpentanamide