(2S,3S,4S,5S)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-4,5-dimethyl-2-phenyl-pyrrolidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(2S,3S,4S,5S)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-4,5-dimethyl-2-phenyl-pyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.:738613-78-0
Molecular Formula:C₂₆H₂₉F₆NO₃
Molecular Weight:517.512
Hs Code.:

Synonyms:(2S,3S,4S,5S)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-4,5-dimethyl-2-phenyl-pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Property of (2S,3S,4S,5S)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-4,5-dimethyl-2-phenyl-pyrrolidine-1-carboxylic acid tert-butyl ester

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Technology Process of (2S,3S,4S,5S)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-4,5-dimethyl-2-phenyl-pyrrolidine-1-carboxylic acid tert-butyl ester

There total 6 articles about (2S,3S,4S,5S)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-4,5-dimethyl-2-phenyl-pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 886991-04-4
(2S,3S,4S,5S)-3-Hydroxy-4,5-dimethyl-2-phenyl-pyrrolidine-1-carboxylic acid tert-butyl ester

: 32247-96-4
3,5-bis(trifluoromethyl)benzyl bromide

: 738613-78-0
(2S,3S,4S,5S)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-4,5-dimethyl-2-phenyl-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With potassium hexamethylsilazane;
DOI:10.1021/ja057012a

Reference yield:

: C₂₄H₃₄N₂O₃S

: 738613-78-0
(2S,3S,4S,5S)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-4,5-dimethyl-2-phenyl-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: NaHCO₃

2: SmI₂; MeOH / tetrahydrofuran / 20 °C

3: 84 percent / KHMDS

With methanol; samarium diiodide; potassium hexamethylsilazane; sodium hydrogencarbonate; In tetrahydrofuran;
DOI:10.1021/ja057012a

Reference yield:

: C₂₇H₄₂N₂O₃SSi

: 738613-78-0
(2S,3S,4S,5S)-3-(3,5-Bis-trifluoromethyl-benzyloxy)-4,5-dimethyl-2-phenyl-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃ / methanol

2: NaHCO₃

3: SmI₂; MeOH / tetrahydrofuran / 20 °C

4: 84 percent / KHMDS

With methanol; samarium diiodide; potassium hexamethylsilazane; sodium hydrogencarbonate; potassium carbonate; In tetrahydrofuran; methanol;
DOI:10.1021/ja057012a