Technology Process of N-[2-(2,5-di-thiophen-2-yl-pyrrol-1-yl)-ethyl]-N'-[4-(10-isobutyl-2,4-dioxo-7-trifluoromethyl-4,10-dihydro-2H-benzo[g]pteridin-3-ylmethyl)-phenyl]-succinamide
There total 9 articles about N-[2-(2,5-di-thiophen-2-yl-pyrrol-1-yl)-ethyl]-N'-[4-(10-isobutyl-2,4-dioxo-7-trifluoromethyl-4,10-dihydro-2H-benzo[g]pteridin-3-ylmethyl)-phenyl]-succinamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 25 percent / boron oxide; acetic acid / 3 h / 80 °C
2: 24 percent / potassium carbonate / dimethylformamide / 6 h / 90 °C
3: 45 percent / ammonium formate / Pd/C / methanol; acetone / 1 h / 20 °C
4: 47 percent / pyridine / 16 h / 20 °C
5: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 48 h / 20 °C
6: 0.62 g / 4-dimethylaminopyridine / dimethylformamide / 48 h / 20 °C
With
pyridine; dmap; boron trioxide; ammonium formate; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
palladium on activated charcoal;
In
methanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ol060620q
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 96 percent / ammonium formate / Pd on carbon / methanol / 2 h / 20 °C
2: 25 percent / boron oxide; acetic acid / 3 h / 80 °C
3: 24 percent / potassium carbonate / dimethylformamide / 6 h / 90 °C
4: 45 percent / ammonium formate / Pd/C / methanol; acetone / 1 h / 20 °C
5: 47 percent / pyridine / 16 h / 20 °C
6: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 48 h / 20 °C
7: 0.62 g / 4-dimethylaminopyridine / dimethylformamide / 48 h / 20 °C
With
pyridine; dmap; boron trioxide; ammonium formate; potassium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
palladium on activated charcoal;
In
methanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ol060620q
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 24 percent / potassium carbonate / dimethylformamide / 6 h / 90 °C
2: 45 percent / ammonium formate / Pd/C / methanol; acetone / 1 h / 20 °C
3: 47 percent / pyridine / 16 h / 20 °C
4: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 48 h / 20 °C
5: 0.62 g / 4-dimethylaminopyridine / dimethylformamide / 48 h / 20 °C
With
pyridine; dmap; ammonium formate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
palladium on activated charcoal;
In
methanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/ol060620q
