1,1-Bis(6-cyano-2-pyridyl)-1-methoxy-1-<3-<(tert-butyldimethylsilyl)oxy>phenyl>methane

Base Information

Chemical Name:1,1-Bis(6-cyano-2-pyridyl)-1-methoxy-1-<3-<(tert-butyldimethylsilyl)oxy>phenyl>methane
CAS No.:155820-16-9
Molecular Formula:C₂₆H₂₈N₄O₂Si
Molecular Weight:456.619
Hs Code.:

Synonyms:1,1-Bis(6-cyano-2-pyridyl)-1-methoxy-1-<3-<(tert-butyldimethylsilyl)oxy>phenyl>methane

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Chemical Property of 1,1-Bis(6-cyano-2-pyridyl)-1-methoxy-1-<3-<(tert-butyldimethylsilyl)oxy>phenyl>methane

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Technology Process of 1,1-Bis(6-cyano-2-pyridyl)-1-methoxy-1-<3-<(tert-butyldimethylsilyl)oxy>phenyl>methane

There total 4 articles about 1,1-Bis(6-cyano-2-pyridyl)-1-methoxy-1-<3-<(tert-butyldimethylsilyl)oxy>phenyl>methane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19437-26-4
2,2'-dipyridyl ketone

: 155820-16-9
1,1-Bis(6-cyano-2-pyridyl)-1-methoxy-1-<3-<(tert-butyldimethylsilyl)oxy>phenyl>methane

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Mg, BrCH₂CH₂Br / 1.) THF, 2.) THF, r.t., 16 h

2: 71 percent / NaH / tetrahydrofuran / 1.) r.t., 1 h, 2.) r.t., 15 h

3: 86 percent / m-CPBA / CH₂Cl₂ / 48 h / Ambient temperature

4: 1.) N,N-dimethylcarbamoyl chloride / 1.) CH₂Cl₂, 4 h, 2.) 7 d

With sodium hydride; magnesium; ethylene dibromide; 3-chloro-benzenecarboperoxoic acid; N,N-Dimethylcarbamoyl chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00087a012

Reference yield:

: 65423-56-5
1-bromo-3-[(tert-butyldimethylsilyl)oxy]benzene

: 155820-16-9
1,1-Bis(6-cyano-2-pyridyl)-1-methoxy-1-<3-<(tert-butyldimethylsilyl)oxy>phenyl>methane

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Mg, BrCH₂CH₂Br / 1.) THF, 2.) THF, r.t., 16 h

2: 71 percent / NaH / tetrahydrofuran / 1.) r.t., 1 h, 2.) r.t., 15 h

3: 86 percent / m-CPBA / CH₂Cl₂ / 48 h / Ambient temperature

4: 1.) N,N-dimethylcarbamoyl chloride / 1.) CH₂Cl₂, 4 h, 2.) 7 d

With sodium hydride; magnesium; ethylene dibromide; 3-chloro-benzenecarboperoxoic acid; N,N-Dimethylcarbamoyl chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00087a012

Reference yield:

: 155820-14-7
1,1-Di(2-pyridyl)-1-<3-<(tert-butyldimethylsilyl)oxy>phenyl>methanol

: 155820-16-9
1,1-Bis(6-cyano-2-pyridyl)-1-methoxy-1-<3-<(tert-butyldimethylsilyl)oxy>phenyl>methane

Guidance literature:: Multi-step reaction with 3 steps

1: 71 percent / NaH / tetrahydrofuran / 1.) r.t., 1 h, 2.) r.t., 15 h

2: 86 percent / m-CPBA / CH₂Cl₂ / 48 h / Ambient temperature

3: 1.) N,N-dimethylcarbamoyl chloride / 1.) CH₂Cl₂, 4 h, 2.) 7 d

With sodium hydride; 3-chloro-benzenecarboperoxoic acid; N,N-Dimethylcarbamoyl chloride; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jo00087a012