5-Methyl-2-oxo-5-(2-thiophen-2-yl-ethyl)-cyclohex-3-enecarboxylic acid methyl ester

Base Information

Chemical Name:5-Methyl-2-oxo-5-(2-thiophen-2-yl-ethyl)-cyclohex-3-enecarboxylic acid methyl ester
CAS No.:197094-82-9
Molecular Formula:C₁₅H₁₈O₃S
Molecular Weight:278.372
Hs Code.:

Synonyms:5-Methyl-2-oxo-5-(2-thiophen-2-yl-ethyl)-cyclohex-3-enecarboxylic acid methyl ester

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Chemical Property of 5-Methyl-2-oxo-5-(2-thiophen-2-yl-ethyl)-cyclohex-3-enecarboxylic acid methyl ester

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Technology Process of 5-Methyl-2-oxo-5-(2-thiophen-2-yl-ethyl)-cyclohex-3-enecarboxylic acid methyl ester

There total 8 articles about 5-Methyl-2-oxo-5-(2-thiophen-2-yl-ethyl)-cyclohex-3-enecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 616-38-6
carbonic acid dimethyl ester

: 197094-81-8
4-Methyl-4-(2-thiophen-2-yl-ethyl)-cyclohex-2-enone

: 197094-82-9
5-Methyl-2-oxo-5-(2-thiophen-2-yl-ethyl)-cyclohex-3-enecarboxylic acid methyl ester

Guidance literature:: With sodium hydride; In tetrahydrofuran; for 4h; Heating;
DOI:10.1016/S0040-4039(97)01514-1

Reference yield:

: 26478-16-0
2-(2-Bromoethyl)thiophene

: 197094-82-9
5-Methyl-2-oxo-5-(2-thiophen-2-yl-ethyl)-cyclohex-3-enecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / lithium diisopropylamide / tetrahydrofuran / 18 h / Heating

2: 1.) lithium aluminum hydride; 2.) hydrochloric acid / 1.) Et₂O, 0 deg C, 15 min

3: 71 percent / sodium hydride / tetrahydrofuran / 4 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; sodium hydride; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1016/S0040-4039(97)01514-1

Reference yield:

: 91950-17-3
ethyl 4-(thiophen-2-yl)butanoate

: 197094-82-9
5-Methyl-2-oxo-5-(2-thiophen-2-yl-ethyl)-cyclohex-3-enecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: lithium diisopropylamide / tetrahydrofuran / 0.25 h / -78 °C

2: lithium aluminum hydride / diethyl ether / 0.33 h / 0 °C

3: pyridinium chlorochromate / CH₂Cl₂ / 1 h / Ambient temperature

4: 1.) pyrrolidine / 1.) C₆H₆, reflux, 16 h; 2.) C₆H₆,, r.t., 3 h

5: 71 percent / sodium hydride / tetrahydrofuran / 4 h / Heating

With pyrrolidine; lithium aluminium tetrahydride; sodium hydride; pyridinium chlorochromate; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/S0040-4039(97)01514-1