(2S,3aS,5R,7aR)-5,6-Dibromo-2-phenyl-hexahydro-benzo[1,3]dioxole

Base Information

• Chemical Name: (2S,3aS,5R,7aR)-5,6-Dibromo-2-phenyl-hexahydro-benzo[1,3]dioxole
• CAS No.: 92241-43-5
• Molecular Formula: C₁₃H₁₄Br₂O₂
• Molecular Weight: 362.061
• Mol file: 92241-43-5.mol

Synonyms:(2S,3aS,5R,7aR)-5,6-Dibromo-2-phenyl-hexahydro-benzo[1,3]dioxole

Chemical Property of (2S,3aS,5R,7aR)-5,6-Dibromo-2-phenyl-hexahydro-benzo[1,3]dioxole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,3aS,5R,7aR)-5,6-Dibromo-2-phenyl-hexahydro-benzo[1,3]dioxole

There total 3 articles about (2S,3aS,5R,7aR)-5,6-Dibromo-2-phenyl-hexahydro-benzo[1,3]dioxole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

benzaldehyde dimethyl acetal (1125-88-8) + [1R(S),2S(R),4S(R),5S(R)]-4,5-dibromocyclohexane-1,2-diol (64287-98-5,80446-29-3,135820-84-7,144607-51-2) → (2α,3aβ,5β,6α,7aβ)-5,6-dibromohexahydro-2-phenyl-1,3-benzodioxole (80409-80-9,92241-42-4,92241-43-5,144562-49-2,144562-50-5)

Guidance literature:

DOI:10.1021/ja00367a038

Reference yield:

cyclohexa-1,4-diene (1165952-92-0) → (2α,3aβ,5β,6α,7aβ)-5,6-dibromohexahydro-2-phenyl-1,3-benzodioxole (80409-80-9,92241-42-4,92241-43-5,144562-49-2,144562-50-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 87 percent / Br₂

2: 49 percent / KMnO₄

3: 98 percent

With potassium permanganate; bromine;

DOI:10.1021/ja00367a038

Reference yield:

trans-4,5-dibromo-1-cyclohexene (42846-36-6,62199-53-5,137053-65-7) → (2α,3aβ,5β,6α,7aβ)-5,6-dibromohexahydro-2-phenyl-1,3-benzodioxole (80409-80-9,92241-42-4,92241-43-5,144562-49-2,144562-50-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 49 percent / KMnO₄

2: 98 percent

With potassium permanganate;

DOI:10.1021/ja00367a038

upstream raw materials:

benzaldehyde dimethyl acetal

[1R(S),2S(R),4S(R),5S(R)]-4,5-dibromocyclohexane-1,2-diol

cyclohexa-1,4-diene

trans-4,5-dibromo-1-cyclohexene

Downstream raw materials:

(2α,3aα,5aβ,6α,6aβ,8β,9aβ,10α,10aβ,10bα)-3a,5a,6,6a,9a,10,10a,10b-octahydro-2,8-diphenyl-6,10-ethenonaphtho<1,2-d:6,7-d'>bis<1,3>dioxole

(2α,3aβ,4α,4aβ,7aβ,8α,8aβ)-4a,7a,8,8a-tetrahydro-2,6-diphenyl-4,8-etheno-4H-1,3-dioxolo<4,5-f>isoindole-5,7(3aH,6H)-dione

(2α,3aα,4β,4aα,7aα,8β,8aα)-4a,7a,8,8a-tetrahydro-2,6-diphenyl-4,8-etheno-4H-1,3-dioxolo<4,5-f>isoindole-5,7(3aH,6H)-dione

(2α,3aα,4α,4aβ,7aβ,8α,8aα)-4a,7a,8,8a-tetrahydro-2,6-diphenyl-4,8-etheno-4H-1,3-dioxolo<4,5-f>isoindole-5,7(3aH,6H)-dione