((R)-(-)-3',5'-Dimethoxybenzoinyl)(2'-cyanoethoxy)(N,N-diisopropylamino)phosphine

Base Information

Chemical Name:((R)-(-)-3',5'-Dimethoxybenzoinyl)(2'-cyanoethoxy)(N,N-diisopropylamino)phosphine
CAS No.:156904-29-9
Molecular Formula:C₂₅H₃₃N₂O₅P
Molecular Weight:472.521
Hs Code.:

Synonyms:((R)-(-)-3',5'-Dimethoxybenzoinyl)(2'-cyanoethoxy)(N,N-diisopropylamino)phosphine

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Chemical Property of ((R)-(-)-3',5'-Dimethoxybenzoinyl)(2'-cyanoethoxy)(N,N-diisopropylamino)phosphine

Chemical Property:

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Technology Process of ((R)-(-)-3',5'-Dimethoxybenzoinyl)(2'-cyanoethoxy)(N,N-diisopropylamino)phosphine

There total 4 articles about ((R)-(-)-3',5'-Dimethoxybenzoinyl)(2'-cyanoethoxy)(N,N-diisopropylamino)phosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7311-34-4
3,5-dimethoxybenzaldehdye

: 156904-29-9
((R)-(-)-3',5'-Dimethoxybenzoinyl)(2'-cyanoethoxy)(N,N-diisopropylamino)phosphine

Guidance literature:: Multi-step reaction with 3 steps

1: diisopropyl L-tartrate, titanium tetraisopropoxide / CH₂Cl₂ / 1.) 0 deg C, 6 h, 2.) 25 deg C, 12 h

2: 2.) 2 N HCl / 1.) ether, reflux, 3 h, 2.) THF, 12 h

3: diisopropylethylamine / acetonitrile / 1 h / 0 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; titanium(IV) isopropylate; L-(+)-diisopropyl tartrate; In dichloromethane; acetonitrile;
DOI:10.1021/jo00093a021

Reference yield:

: phenylmagnesium bromide

: 156904-29-9
((R)-(-)-3',5'-Dimethoxybenzoinyl)(2'-cyanoethoxy)(N,N-diisopropylamino)phosphine

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) 2 N HCl / 1.) ether, reflux, 3 h, 2.) THF, 12 h

2: diisopropylethylamine / acetonitrile / 1 h / 0 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In acetonitrile;
DOI:10.1021/jo00093a021

Reference yield:

: 156904-44-8
2-(3,5-dimethoxyphenyl)-2-hydroxyacetonitrile

: 156904-29-9
((R)-(-)-3',5'-Dimethoxybenzoinyl)(2'-cyanoethoxy)(N,N-diisopropylamino)phosphine

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / imidazole / dimethylformamide / 1 h / 25 °C

2: 2.) 2 N HCl / 1.) ether, reflux, 3 h, 2.) THF, 12 h

3: diisopropylethylamine / acetonitrile / 1 h / 0 °C

With 1H-imidazole; hydrogenchloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00093a021