Lidoflazine

Base Information

• Chemical Name: Lidoflazine
• CAS No.: 3416-26-0
• Molecular Formula: C30H35 F2 N3 O
• Molecular Weight: 491.624
• European Community (EC) Number: 222-312-8
• UNII: J4ZHN3HBTE
• DSSTox Substance ID: DTXSID6045377
• Nikkaji Number: J7.732A
• Wikipedia: Lidoflazine
• Wikidata: Q6543740
• NCI Thesaurus Code: C81685
• Pharos Ligand ID: CVQ3SH9S3ZU4
• Metabolomics Workbench ID: 154546
• ChEMBL ID: CHEMBL92870
• Mol file: 3416-26-0.mol

Synonyms:Clinium;Lidoflazine;Ordiflazine

Chemical Property of Lidoflazine

Chemical Property:

• Vapor Pressure: 6.57E-16mmHg at 25°C
• Melting Point: 158-162℃
• Boiling Point: 632.6°Cat760mmHg
• PKA: 14.62±0.70(Predicted)
• Flash Point: 336.4°C
• PSA: 35.58000
• Density: 1.161g/cm³
• LogP: 5.69880
• Storage Temp.: 2-8°C
• Solubility.: DMSO: ≥10mg/mL
• XLogP3: 6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 9
• Exact Mass: 491.27481907
• Heavy Atom Count: 36
• Complexity: 623

Purity/Quality:

97% ^*data from raw suppliers

Lidoflazine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=CC=C1)C)NC(=O)CN2CCN(CC2)CCCC(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F
• Uses: Coronary vasodilatator;Ca++ channel activator Lidoflazine is a L-type Ca2+ channel antagonist.Also, it is derived from 1,1''-(4-Chlorobutylidene)bis(4-fluorobenzene) (C364775), which is a derivative of Zerumbone with potential anti-tumor effects towards HeLa cancer cells.
• Therapeutic Function: Coronary vasodilator

Technology Process of Lidoflazine

There total 1 articles about Lidoflazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ lidoflazine (3416-26-0)

Guidance literature:

entspr. Piperazin VII R=H, entspr. Halogenid;

Refernces

Some new prazosin analogues

10.1002/ardp.19893220607

Prazosin, a selective a1-adrenergic antagonist used in antihypertensive therapy, has limitations due to its short half-life and side effects. To address these issues, the researchers synthesized new analogues by modifying the C-2 side-chain of prazosin, incorporating fragments from tienilic acid, guanethidine, and lidoflazine. The compounds were synthesized using various chemical procedures and their structures were confirmed through analytical data. The pharmacological properties were evaluated in terms of acute toxicity and hypotensive effects in mice and genetically hypertensive rats, respectively. The results showed that compound 5, featuring a tienilic residue in place of the furan ring, exhibited the highest hypotensive effect and a more long-lasting activity compared to prazosin. The study concludes that the new compounds, particularly compound 5, have potential for improved pharmacokinetic properties and hypotensive activity, warranting further investigation for their therapeutic applications.