2-Amino-4-(2-(p-methylphenylthio)-6-methoxyquinolin-3-yl)-5-oxo-7-methyl-4,5-dihydropyrano[4,3-b]pyran-3-carbonitrile

Base Information

• Chemical Name: 2-Amino-4-(2-(p-methylphenylthio)-6-methoxyquinolin-3-yl)-5-oxo-7-methyl-4,5-dihydropyrano[4,3-b]pyran-3-carbonitrile
• CAS No.: 1376342-42-5
• Molecular Formula: C₂₇H₂₁N₃O₄S
• Molecular Weight: 483.547

Synonyms:2-Amino-4-(2-(p-methylphenylthio)-6-methoxyquinolin-3-yl)-5-oxo-7-methyl-4,5-dihydropyrano[4,3-b]pyran-3-carbonitrile

Chemical Property of 2-Amino-4-(2-(p-methylphenylthio)-6-methoxyquinolin-3-yl)-5-oxo-7-methyl-4,5-dihydropyrano[4,3-b]pyran-3-carbonitrile

Chemical Property:

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Technology Process of 2-Amino-4-(2-(p-methylphenylthio)-6-methoxyquinolin-3-yl)-5-oxo-7-methyl-4,5-dihydropyrano[4,3-b]pyran-3-carbonitrile

There total 3 articles about 2-Amino-4-(2-(p-methylphenylthio)-6-methoxyquinolin-3-yl)-5-oxo-7-methyl-4,5-dihydropyrano[4,3-b]pyran-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

4-hydroxy-6-methyl-2-pyron (675-10-5) + C18H15NO2S (1376342-19-6) + malononitrile (109-77-3) → 2-Amino-4-(2-(p-methylphenylthio)-6-methoxyquinolin-3-yl)-5-oxo-7-methyl-4,5-dihydropyrano[4,3-b]pyran-3-carbonitrile (1376342-42-5)

Guidance literature:

With potassium hydroxide; In ethanol; at 20 ℃;

DOI:10.1002/ardp.201100203

Reference yield:

2-chloro-6-methoxyquinolin-3-carboxaldehyde (73568-29-3) → 2-Amino-4-(2-(p-methylphenylthio)-6-methoxyquinolin-3-yl)-5-oxo-7-methyl-4,5-dihydropyrano[4,3-b]pyran-3-carbonitrile (1376342-42-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / Reflux

2: potassium hydroxide / ethanol / 20 °C

With potassium carbonate; potassium hydroxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1002/ardp.201100203

Reference yield:

para-thiocresol (106-45-6) → 2-Amino-4-(2-(p-methylphenylthio)-6-methoxyquinolin-3-yl)-5-oxo-7-methyl-4,5-dihydropyrano[4,3-b]pyran-3-carbonitrile (1376342-42-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2.5 h / Reflux

2: potassium hydroxide / ethanol / 20 °C

With potassium carbonate; potassium hydroxide; In ethanol; N,N-dimethyl-formamide;

DOI:10.1002/ardp.201100203

upstream raw materials:

4-hydroxy-6-methyl-2-pyron

C₁₈H₁₅NO₂S

malononitrile

2-chloro-6-methoxyquinolin-3-carboxaldehyde

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