(+/-)-(E)-2-[2-(morpholinoacetoxy)pentyl]benzoic acid {2-methoxy-4-[2-(3-nitrooxypropoxycarbonyl)vinyl]}phenyl ester hydrochloride

Base Information

• Chemical Name: (+/-)-(E)-2-[2-(morpholinoacetoxy)pentyl]benzoic acid {2-methoxy-4-[2-(3-nitrooxypropoxycarbonyl)vinyl]}phenyl ester hydrochloride
• CAS No.: 1330531-08-2
• Molecular Formula: C₃₁H₃₈N₂O₁₁*ClH
• Molecular Weight: 651.11
• Mol file: 1330531-08-2.mol

Synonyms:(+/-)-(E)-2-[2-(morpholinoacetoxy)pentyl]benzoic acid {2-methoxy-4-[2-(3-nitrooxypropoxycarbonyl)vinyl]}phenyl ester hydrochloride

Chemical Property of (+/-)-(E)-2-[2-(morpholinoacetoxy)pentyl]benzoic acid {2-methoxy-4-[2-(3-nitrooxypropoxycarbonyl)vinyl]}phenyl ester hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-(E)-2-[2-(morpholinoacetoxy)pentyl]benzoic acid {2-methoxy-4-[2-(3-nitrooxypropoxycarbonyl)vinyl]}phenyl ester hydrochloride

There total 7 articles about (+/-)-(E)-2-[2-(morpholinoacetoxy)pentyl]benzoic acid {2-methoxy-4-[2-(3-nitrooxypropoxycarbonyl)vinyl]}phenyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

morpholine (110-91-8,99108-56-2) + (+/-)-(E)-2-(2-chloroacetoxypentyl)benzoic acid {2-methoxy-4-[2-(3-nitrooxypropoxycarbonyl)vinyl]}phenyl ester (1330531-02-6) → (+/-)-(E)-2-[2-(morpholinoacetoxy)pentyl]benzoic acid {2-methoxy-4-[2-(3-nitrooxypropoxycarbonyl)vinyl]}phenyl ester hydrochloride (1330531-08-2)

Guidance literature:

morpholine; (+/-)-(E)-2-(2-chloroacetoxypentyl)benzoic acid {2-methoxy-4-[2-(3-nitrooxypropoxycarbonyl)vinyl]}phenyl ester; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 8h;

With hydrogenchloride; In diethyl ether; at 0 - 20 ℃; for 1h;

DOI:10.1039/c1ob05478c

Reference yield:

(E)-3-bromopropyl 3-(4-hydroxy-3-methoxyphenyl)acrylate (1257642-03-7) → (+/-)-(E)-2-[2-(morpholinoacetoxy)pentyl]benzoic acid {2-methoxy-4-[2-(3-nitrooxypropoxycarbonyl)vinyl]}phenyl ester hydrochloride (1330531-08-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: silver nitrate / acetonitrile / 2 h / Darkness; Heating

2.1: dmap / dichloromethane / 0.17 h / 0 °C

2.2: 20 °C

3.1: triethylamine / N,N-dimethyl-formamide / 8 h / 20 °C

3.2: 1 h / 0 - 20 °C

With dmap; silver nitrate; triethylamine; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1039/c1ob05478c

Reference yield:

(+/-)-2-[1-(2-chloroacetoxy)pentyl]benzoic acid (1107060-38-7) → (+/-)-(E)-2-[2-(morpholinoacetoxy)pentyl]benzoic acid {2-methoxy-4-[2-(3-nitrooxypropoxycarbonyl)vinyl]}phenyl ester hydrochloride (1330531-08-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dmap / dichloromethane / 0.17 h / 0 °C

1.2: 20 °C

2.1: triethylamine / N,N-dimethyl-formamide / 8 h / 20 °C

2.2: 1 h / 0 - 20 °C

With dmap; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1039/c1ob05478c

upstream raw materials:

morpholine

(+/-)-(E)-2-(2-chloroacetoxypentyl)benzoic acid {2-methoxy-4-[2-(3-nitrooxypropoxycarbonyl)vinyl]}phenyl ester

(+/-)-2-[1-(2-chloroacetoxy)pentyl]benzoic acid

(E)-3-(nitrooxy)propyl 3-(4-hydroxy-3-methoxyphenyl)acrylate