5'-O-(tert-butyldiphenylsilyl)-3'-O-(methylthiomethyl)-2'-deoxythymidine

Base Information

• Chemical Name: 5'-O-(tert-butyldiphenylsilyl)-3'-O-(methylthiomethyl)-2'-deoxythymidine
• CAS No.: 1608114-29-9
• Molecular Formula: C₂₇H₃₃ClN₂O₅Si
• Molecular Weight: 529.108
• Mol file: 1608114-29-9.mol

Synonyms:5'-O-(tert-butyldiphenylsilyl)-3'-O-(methylthiomethyl)-2'-deoxythymidine

Chemical Property of 5'-O-(tert-butyldiphenylsilyl)-3'-O-(methylthiomethyl)-2'-deoxythymidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5'-O-(tert-butyldiphenylsilyl)-3'-O-(methylthiomethyl)-2'-deoxythymidine

There total 4 articles about 5'-O-(tert-butyldiphenylsilyl)-3'-O-(methylthiomethyl)-2'-deoxythymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5'-O-(tert-butyldiphenylsilyl)-3'-O-(methylthiomethyl)-2'-deoxythymidine (1215169-94-0) → 5'-O-(tert-butyldiphenylsilyl)-3'-O-(methylthiomethyl)-2'-deoxythymidine (1608114-29-9)

Guidance literature:

With sulfuryl dichloride; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;

DOI:10.1002/ejoc.201301781

Reference yield:

thymidine (50-89-5,28854-96-8,3545-96-8,50-88-4) → 5'-O-(tert-butyldiphenylsilyl)-3'-O-(methylthiomethyl)-2'-deoxythymidine (1608114-29-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

2: acetic acid; acetic anhydride / 48 h / 20 °C / Inert atmosphere

3: sulfuryl dichloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; sulfuryl dichloride; acetic anhydride; acetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/ejoc.201301781

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → 5'-O-(tert-butyldiphenylsilyl)-3'-O-(methylthiomethyl)-2'-deoxythymidine (1608114-29-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

2: acetic acid; acetic anhydride / 48 h / 20 °C / Inert atmosphere

3: sulfuryl dichloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; sulfuryl dichloride; acetic anhydride; acetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/ejoc.201301781

upstream raw materials:

thymidine

tert-butylchlorodiphenylsilane

5'-O-tert-butyldiphenylsilylthymidine

5'-O-(tert-butyldiphenylsilyl)-3'-O-(methylthiomethyl)-2'-deoxythymidine

Downstream raw materials:

C₃₃H₃₂N₃O₁₁P

C₂₅H₃₀N₃O₉P

C₃₇H₄₈N₅O₁₄PS

C₃₆H₄₇N₆O₁₃PS