methyl (R,S)-8-chlorocarbonyl-1,2,4,5-tetrahydro-3-oxo-4-(2-phenylethyl)-3H-1,4-benzodiazepine-2-acetate

Base Information

• Chemical Name: methyl (R,S)-8-chlorocarbonyl-1,2,4,5-tetrahydro-3-oxo-4-(2-phenylethyl)-3H-1,4-benzodiazepine-2-acetate
• CAS No.: 161014-59-1
• Molecular Formula: C₂₁H₂₁ClN₂O₄
• Molecular Weight: 400.862
• Mol file: 161014-59-1.mol

Synonyms:methyl (R,S)-8-chlorocarbonyl-1,2,4,5-tetrahydro-3-oxo-4-(2-phenylethyl)-3H-1,4-benzodiazepine-2-acetate

Chemical Property of methyl (R,S)-8-chlorocarbonyl-1,2,4,5-tetrahydro-3-oxo-4-(2-phenylethyl)-3H-1,4-benzodiazepine-2-acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (R,S)-8-chlorocarbonyl-1,2,4,5-tetrahydro-3-oxo-4-(2-phenylethyl)-3H-1,4-benzodiazepine-2-acetate

There total 11 articles about methyl (R,S)-8-chlorocarbonyl-1,2,4,5-tetrahydro-3-oxo-4-(2-phenylethyl)-3H-1,4-benzodiazepine-2-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

→ methyl (R,S)-8-chlorocarbonyl-1,2,4,5-tetrahydro-3-oxo-4-(2-phenylethyl)-3H-1,4-benzodiazepine-2-acetate (161014-59-1) + methyl (R,S)-8-azidocarbonyl-1,2,4,5-tetrahydro-3-oxo-4-(2-phenylethyl)-3H-1,4-benzodiazepine-2-acetate (165528-98-3)

Guidance literature:

Reference yield:

2-nitro-4-(tert-butoxycarbonyl)benzyl bromide (65276-90-6) → methyl (R,S)-8-chlorocarbonyl-1,2,4,5-tetrahydro-3-oxo-4-(2-phenylethyl)-3H-1,4-benzodiazepine-2-acetate (161014-59-1)

Guidance literature:

Multi-step reaction with 8 steps

1: 90 percent

2: 85 percent

3: 80 percent / H₂ / 10percent Pd/C

4: 80 percent

5: 98 percent / H₂ / 10percent Pd/C

6: 95 percent / CF₃COOH

7: 55 percent / NaOCH₃ / methanol

8: SOCl₂

With thionyl chloride; hydrogen; sodium methylate; trifluoroacetic acid; palladium on activated charcoal; In methanol;

DOI:10.1021/ja00072a058

Reference yield:

phenethylamine (64-04-0) → methyl (R,S)-8-chlorocarbonyl-1,2,4,5-tetrahydro-3-oxo-4-(2-phenylethyl)-3H-1,4-benzodiazepine-2-acetate (161014-59-1)

Guidance literature:

Multi-step reaction with 8 steps

1: 90 percent

2: 85 percent

3: 80 percent / H₂ / 10percent Pd/C

4: 80 percent

5: 98 percent / H₂ / 10percent Pd/C

6: 95 percent / CF₃COOH

7: 55 percent / NaOCH₃ / methanol

8: SOCl₂

With thionyl chloride; hydrogen; sodium methylate; trifluoroacetic acid; palladium on activated charcoal; In methanol;

DOI:10.1021/ja00072a058

upstream raw materials:

methyl (R,S)-8-carboxy-2,3,4,5-tetrahydro-3-oxo-4-(2-phenylethyl)-1H-1,4-benzodiazepine-2-acetate

2-nitro-4-(tert-butoxycarbonyl)benzyl bromide

phenethylamine

3-Nitro-4-(phenethylamino-methyl)-benzoic acid tert-butyl ester

Downstream raw materials:

[8-(4-{Amino-[(Z)-benzyloxycarbonylimino]-methyl}-phenylcarbamoyl)-3-oxo-4-phenethyl-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl]-acetic acid methyl ester

methyl (R,S)-2,3,4,5-tetrahydro-8-(hydroxymethyl)-3-oxo-4-(2-phenylethyl)-1H-1,4-benzodiazepine-2-acetate

methyl (R,S)-8-azidocarbonyl-1,2,4,5-tetrahydro-3-oxo-4-(2-phenylethyl)-3H-1,4-benzodiazepine-2-acetate

methyl (R,S)-8-amino-1,2,4,5-tetrahydro-3-oxo-4-(2-phenylethyl)-3H-1,4-benzodiazepine-2-acetate