methyl (R,S)-8-chlorocarbonyl-1,2,4,5-tetrahydro-3-oxo-4-(2-phenylethyl)-3H-1,4-benzodiazepine-2-acetate

Base Information

Chemical Name:methyl (R,S)-8-chlorocarbonyl-1,2,4,5-tetrahydro-3-oxo-4-(2-phenylethyl)-3H-1,4-benzodiazepine-2-acetate
CAS No.:161014-59-1
Molecular Formula:C₂₁H₂₁ClN₂O₄
Molecular Weight:400.862
Hs Code.:

Synonyms:methyl (R,S)-8-chlorocarbonyl-1,2,4,5-tetrahydro-3-oxo-4-(2-phenylethyl)-3H-1,4-benzodiazepine-2-acetate

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Chemical Property of methyl (R,S)-8-chlorocarbonyl-1,2,4,5-tetrahydro-3-oxo-4-(2-phenylethyl)-3H-1,4-benzodiazepine-2-acetate

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Technology Process of methyl (R,S)-8-chlorocarbonyl-1,2,4,5-tetrahydro-3-oxo-4-(2-phenylethyl)-3H-1,4-benzodiazepine-2-acetate

There total 11 articles about methyl (R,S)-8-chlorocarbonyl-1,2,4,5-tetrahydro-3-oxo-4-(2-phenylethyl)-3H-1,4-benzodiazepine-2-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 161014-59-1
methyl (R,S)-8-chlorocarbonyl-1,2,4,5-tetrahydro-3-oxo-4-(2-phenylethyl)-3H-1,4-benzodiazepine-2-acetate

: 165528-98-3
methyl (R,S)-8-azidocarbonyl-1,2,4,5-tetrahydro-3-oxo-4-(2-phenylethyl)-3H-1,4-benzodiazepine-2-acetate

Guidance literature:

Reference yield:

: 65276-90-6
2-nitro-4-(tert-butoxycarbonyl)benzyl bromide

: 161014-59-1
methyl (R,S)-8-chlorocarbonyl-1,2,4,5-tetrahydro-3-oxo-4-(2-phenylethyl)-3H-1,4-benzodiazepine-2-acetate

Guidance literature:: Multi-step reaction with 8 steps

1: 90 percent

2: 85 percent

3: 80 percent / H₂ / 10percent Pd/C

4: 80 percent

5: 98 percent / H₂ / 10percent Pd/C

6: 95 percent / CF₃COOH

7: 55 percent / NaOCH₃ / methanol

8: SOCl₂

With thionyl chloride; hydrogen; sodium methylate; trifluoroacetic acid; palladium on activated charcoal; In methanol;
DOI:10.1021/ja00072a058

Reference yield:

: 64-04-0
phenethylamine

: 161014-59-1
methyl (R,S)-8-chlorocarbonyl-1,2,4,5-tetrahydro-3-oxo-4-(2-phenylethyl)-3H-1,4-benzodiazepine-2-acetate

Guidance literature:: Multi-step reaction with 8 steps

1: 90 percent

2: 85 percent

3: 80 percent / H₂ / 10percent Pd/C

4: 80 percent

5: 98 percent / H₂ / 10percent Pd/C

6: 95 percent / CF₃COOH

7: 55 percent / NaOCH₃ / methanol

8: SOCl₂

With thionyl chloride; hydrogen; sodium methylate; trifluoroacetic acid; palladium on activated charcoal; In methanol;
DOI:10.1021/ja00072a058