Technology Process of (E)-(4R,5R,9S,10R,12R,13S)-16-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-4,10-dimethoxy-12-methoxymethoxy-5,9,13-trimethyl-hexadec-7-en-6-one
There total 23 articles about (E)-(4R,5R,9S,10R,12R,13S)-16-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-4,10-dimethoxy-12-methoxymethoxy-5,9,13-trimethyl-hexadec-7-en-6-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 11 steps
1: 70 percent / (-)-DET, Ti(OiPr)4, tBuOOH
2: 50 percent / CuI
3: 100 percent
4: 78 percent / NaH
5: 80 percent / Bu4NF
6: 72 percent / PDC / dimethylformamide
7: 91 percent / AcCl
8: 98 percent / H2 / Pd(OH)2-C
9: 98 percent
10: 89 percent / BuLi
11: 79 percent / potassium hexamethyldisilylazide / -78 °C
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; dipyridinium dichromate; n-butyllithium; potassium hexamethyldisilylazide; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; (-)-diethyl tartrate; acetyl chloride;
copper(l) iodide; palladium hydroxide - carbon;
In
N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)79858-3
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 50 percent / CuI
2: 100 percent
3: 78 percent / NaH
4: 80 percent / Bu4NF
5: 72 percent / PDC / dimethylformamide
6: 91 percent / AcCl
7: 98 percent / H2 / Pd(OH)2-C
8: 98 percent
9: 89 percent / BuLi
10: 79 percent / potassium hexamethyldisilylazide / -78 °C
With
dipyridinium dichromate; n-butyllithium; potassium hexamethyldisilylazide; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; acetyl chloride;
copper(l) iodide; palladium hydroxide - carbon;
In
N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)79858-3
