Des(pyrrolidinyl)diethylamino ormeloxifene

Base Information

Chemical Name:Des(pyrrolidinyl)diethylamino ormeloxifene
CAS No.:78994-27-1
Molecular Formula:C₃₀H₃₇NO₃
Molecular Weight:459.629
Hs Code.:
UNII:ACK63NL9ZV

Synonyms:ACK63NL9ZV;Des(pyrrolidinyl)diethylamino ormeloxifene;UNII-ACK63NL9ZV;Des(pyrrolidinyl) diethylamino centchroman;Des(pyrrolidinyl) diethylamino centchroman, (+/-)-;78994-27-1;Ethanamine, 2-(4-(3,4-dihydro-7-methoxy-2,2-dimethyl-3-phenyl-2H-1-benzopyran-4-yl)phenoxy)-N,N-diethyl-, trans-;N,N-Diethyl-2-(4-((3R,4R)-7-methoxy-2,2-dimethyl-3-phenyl-3,4-dihydrochromen-4-yl)phenoxy)ethanamine

Suppliers and Price of Des(pyrrolidinyl)diethylamino ormeloxifene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Des(pyrrolidinyl)diethylamino ormeloxifene

Chemical Property:

XLogP3:6.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:9
Exact Mass:459.27734404
Heavy Atom Count:34
Complexity:592

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCN(CC)CCOC1=CC=C(C=C1)C2C(C(OC3=C2C=CC(=C3)OC)(C)C)C4=CC=CC=C4
Isomeric SMILES:CCN(CC)CCOC1=CC=C(C=C1)[C@H]2[C@@H](C(OC3=C2C=CC(=C3)OC)(C)C)C4=CC=CC=C4

Technology Process of Des(pyrrolidinyl)diethylamino ormeloxifene

There total 4 articles about Des(pyrrolidinyl)diethylamino ormeloxifene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 51423-18-8
cis-2,2-Dimethyl-3-phenyl-4-(p-hydroxyphenyl)-7-methoxychroman

: 78994-27-1
trans-2,2-dimethyl-3-phenyl-4-phenyl>-7-methoxychroman

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / K₂CO₃ / acetone / 35 h / Heating

2: 95 percent / n-BuLi / hexane; dimethylsulfoxide / 16 h / Ambient temperature

3: 93 percent / H₂ / Raney Ni / methanol / 8 h / 3102.9 Torr

4: K₂CO₃ / acetone / 14 h / Heating

With n-butyllithium; hydrogen; potassium carbonate; nickel; In methanol; hexane; dimethyl sulfoxide; acetone;
DOI:10.1021/jm00358a026

Reference yield:

: 84394-05-8
cis-2,2-dimethyl-3-phenyl-4--7-methoxychroman

: 78994-27-1
trans-2,2-dimethyl-3-phenyl-4-phenyl>-7-methoxychroman

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / n-BuLi / hexane; dimethylsulfoxide / 16 h / Ambient temperature

2: 93 percent / H₂ / Raney Ni / methanol / 8 h / 3102.9 Torr

3: K₂CO₃ / acetone / 14 h / Heating

With n-butyllithium; hydrogen; potassium carbonate; nickel; In methanol; hexane; dimethyl sulfoxide; acetone;
DOI:10.1021/jm00358a026

Reference yield:

: 84394-06-9
trans-2,2-dimethyl-3-phenyl-4--7-methoxychroman

: 78994-27-1
trans-2,2-dimethyl-3-phenyl-4-phenyl>-7-methoxychroman

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / H₂ / Raney Ni / methanol / 8 h / 3102.9 Torr

2: K₂CO₃ / acetone / 14 h / Heating

With hydrogen; potassium carbonate; nickel; In methanol; acetone;
DOI:10.1021/jm00358a026