(2Z,4E)-8-[(tert-butyldimethylsilyl)oxy]-3-[[(tert-butyldiphenylsilyl)oxy]methyl]-5-methyl-2,4-octadiene

Base Information

Chemical Name:(2Z,4E)-8-[(tert-butyldimethylsilyl)oxy]-3-[[(tert-butyldiphenylsilyl)oxy]methyl]-5-methyl-2,4-octadiene
CAS No.:193292-38-5
Molecular Formula:C₃₂H₅₀O₂Si₂
Molecular Weight:522.919
Hs Code.:

Synonyms:(2Z,4E)-8-[(tert-butyldimethylsilyl)oxy]-3-[[(tert-butyldiphenylsilyl)oxy]methyl]-5-methyl-2,4-octadiene

Suppliers and Price of (2Z,4E)-8-[(tert-butyldimethylsilyl)oxy]-3-[[(tert-butyldiphenylsilyl)oxy]methyl]-5-methyl-2,4-octadiene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2Z,4E)-8-[(tert-butyldimethylsilyl)oxy]-3-[[(tert-butyldiphenylsilyl)oxy]methyl]-5-methyl-2,4-octadiene

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (2Z,4E)-8-[(tert-butyldimethylsilyl)oxy]-3-[[(tert-butyldiphenylsilyl)oxy]methyl]-5-methyl-2,4-octadiene

There total 7 articles about (2Z,4E)-8-[(tert-butyldimethylsilyl)oxy]-3-[[(tert-butyldiphenylsilyl)oxy]methyl]-5-methyl-2,4-octadiene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1530-32-1
ethyltriphenylphosphonium bromide

: 193292-62-5
(E)-7-[(tert-butyldimethylsilyl)oxy]-1-[(tert-butyldiphenylsilyl)oxy]-4-methyl-3-hepten-2-one

: 193292-38-5
(2Z,4E)-8-[(tert-butyldimethylsilyl)oxy]-3-[[(tert-butyldiphenylsilyl)oxy]methyl]-5-methyl-2,4-octadiene

Guidance literature:: ethyltriphenylphosphonium bromide; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -78 - 0 ℃;

(E)-7-[(tert-butyldimethylsilyl)oxy]-1-[(tert-butyldiphenylsilyl)oxy]-4-methyl-3-hepten-2-one; In tetrahydrofuran; toluene; at -78 - 0 ℃;
DOI:10.1016/S0040-4020(02)00656-7

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 193292-38-5
(2Z,4E)-8-[(tert-butyldimethylsilyl)oxy]-3-[[(tert-butyldiphenylsilyl)oxy]methyl]-5-methyl-2,4-octadiene

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95 percent / 2,6-lutidine / CH₂Cl₂ / 1.5 h / -78 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C

2.2: 98 percent / tetrahydrofuran; hexane / -78 - 0 °C

3.1: copper(I) iodide / tetrahydrofuran; diethyl ether / 0.33 h / 0 °C

3.2: tetrahydrofuran; diethyl ether / 0.25 h / -78 °C

4.1: potassium hexamethyldisilazide / tetrahydrofuran; toluene / -78 - 0 °C

4.2: 88 percent / tetrahydrofuran; toluene / -78 - 0 °C

With 2,6-dimethylpyridine; copper(l) iodide; n-butyllithium; potassium hexamethylsilazane; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; toluene; 4.2: Wittig olefination;
DOI:10.1016/S0040-4020(02)00656-7

Reference yield:

: 5390-04-5
pent-1-yn-5-ol

: 193292-38-5
(2Z,4E)-8-[(tert-butyldimethylsilyl)oxy]-3-[[(tert-butyldiphenylsilyl)oxy]methyl]-5-methyl-2,4-octadiene

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95 percent / 2,6-lutidine / CH₂Cl₂ / 1.5 h / -78 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.33 h / -78 °C

2.2: 98 percent / tetrahydrofuran; hexane / -78 - 0 °C

3.1: copper(I) iodide / tetrahydrofuran; diethyl ether / 0.33 h / 0 °C

3.2: tetrahydrofuran; diethyl ether / 0.25 h / -78 °C

4.1: potassium hexamethyldisilazide / tetrahydrofuran; toluene / -78 - 0 °C

4.2: 88 percent / tetrahydrofuran; toluene / -78 - 0 °C

With 2,6-dimethylpyridine; copper(l) iodide; n-butyllithium; potassium hexamethylsilazane; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; toluene; 4.2: Wittig olefination;
DOI:10.1016/S0040-4020(02)00656-7