(2''RS)-11-<2'-(Methoxymethoxy)phenyl>-1-<(tetrahydropyran-2''-yl)oxy>undecan

Base Information

• Chemical Name: (2''RS)-11-<2'-(Methoxymethoxy)phenyl>-1-<(tetrahydropyran-2''-yl)oxy>undecan
• CAS No.: 139304-82-8
• Molecular Formula: C₂₄H₄₀O₄
• Molecular Weight: 392.579
• Mol file: 139304-82-8.mol

Synonyms:(2''RS)-11-<2'-(Methoxymethoxy)phenyl>-1-<(tetrahydropyran-2''-yl)oxy>undecan

Chemical Property of (2''RS)-11-<2'-(Methoxymethoxy)phenyl>-1-<(tetrahydropyran-2''-yl)oxy>undecan

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2''RS)-11-<2'-(Methoxymethoxy)phenyl>-1-<(tetrahydropyran-2''-yl)oxy>undecan

There total 1 articles about (2''RS)-11-<2'-(Methoxymethoxy)phenyl>-1-<(tetrahydropyran-2''-yl)oxy>undecan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-[(11-bromoundecyl)oxy]tetrahydro-2H-pyran (52056-69-6) + O-methoxymethylphenol (824-91-9) → (2''RS)-11-<2'-(Methoxymethoxy)phenyl>-1-<(tetrahydropyran-2''-yl)oxy>undecan (139304-82-8)

Guidance literature:

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; hexane; at 0 - 2 ℃;

DOI:10.1002/hlca.19910740828

Reference yield: 98.0%

(2''RS)-11-<2'-(Methoxymethoxy)phenyl>-1-<(tetrahydropyran-2''-yl)oxy>undecan (139304-82-8) → 11-(2'-Hydroxyphenyl)undecan-1-ol

Guidance literature:

With toluene-4-sulfonic acid; In methanol;

DOI:10.1002/hlca.19910740828

Reference yield:

(2''RS)-11-<2'-(Methoxymethoxy)phenyl>-1-<(tetrahydropyran-2''-yl)oxy>undecan (139304-82-8) → (6RS)-6-Acetoxy-6-(11'-hydroxyundecyl)cyclohexa-2,4-dien-1-on (139304-84-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / TsOH*H₂O / methanol

2: 79 percent / BF₃*Et₂O / methanol; ethyl acetate / 1) -20 deg C, 2) 0 deg C

With boron trifluoride diethyl etherate; toluene-4-sulfonic acid; In methanol; ethyl acetate;

DOI:10.1002/hlca.19910740828

upstream raw materials:

2-[(11-bromoundecyl)oxy]tetrahydro-2H-pyran

O-methoxymethylphenol

Downstream raw materials:

(6RS)-6-Acetoxy-6-(11'-hydroxyundecyl)cyclohexa-2,4-dien-1-on