N-(2-Chloro-4,6-dimethyl-3-pyridinyl)-2-hydroxybenzamide

Base Information

Chemical Name:N-(2-Chloro-4,6-dimethyl-3-pyridinyl)-2-hydroxybenzamide
CAS No.:140413-41-8
Molecular Formula:C₁₄H₁₃ClN₂O₂
Molecular Weight:276.722
Hs Code.:
DSSTox Substance ID:DTXSID701202276

Synonyms:N-(2-Chloro-4,6-dimethyl-3-pyridinyl)-2-hydroxybenzamide;DTXSID701202276;140413-41-8

Suppliers and Price of N-(2-Chloro-4,6-dimethyl-3-pyridinyl)-2-hydroxybenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of N-(2-Chloro-4,6-dimethyl-3-pyridinyl)-2-hydroxybenzamide

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:276.0665554
Heavy Atom Count:19
Complexity:327

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC(=NC(=C1NC(=O)C2=CC=CC=C2O)Cl)C

Technology Process of N-(2-Chloro-4,6-dimethyl-3-pyridinyl)-2-hydroxybenzamide

There total 4 articles about N-(2-Chloro-4,6-dimethyl-3-pyridinyl)-2-hydroxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 140413-40-7
3-amino-2-chloro-4,6-dimethylpyridine

: 1441-87-8
salicyloyl chloride

: 140413-41-8
N-(2-chloro-4,6-dimethyl-3-pyridyl)salicylamide

Guidance literature:: With triethylamine; In toluene; for 3h; Heating;
DOI:10.1021/jm00088a027

Reference yield:

: 769-28-8,70254-47-6
2-hydroxy-4,6-dimethyl-3-carbonitrile

: 140413-41-8
N-(2-chloro-4,6-dimethyl-3-pyridyl)salicylamide

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / POCl₃ / 3 h / Heating

2: 100 percent / conc. H₂SO₄ / 2 h / 120 °C

3: 75 percent / Br₂, aq. NaOH / 1.) 0 deg C, 1 h, 2.) 70 deg C, 45 min

4: 35 percent / Et₃N / toluene / 3 h / Heating

With sodium hydroxide; sulfuric acid; bromine; triethylamine; trichlorophosphate; In toluene;
DOI:10.1021/jm00088a027

Reference yield:

: 14237-71-9
2-chloro-4,6-dimethylnicotinonitrile

: 140413-41-8
N-(2-chloro-4,6-dimethyl-3-pyridyl)salicylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / conc. H₂SO₄ / 2 h / 120 °C

2: 75 percent / Br₂, aq. NaOH / 1.) 0 deg C, 1 h, 2.) 70 deg C, 45 min

3: 35 percent / Et₃N / toluene / 3 h / Heating

With sodium hydroxide; sulfuric acid; bromine; triethylamine; In toluene;
DOI:10.1021/jm00088a027